{"id":"W4311633668","doi":"10.3389/fcell.2022.1026406","title":"Targets of histone H3 lysine 9 methyltransferases","year":2022,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Histone methyltransferase; EZH2; Histone methylation; Biology; Methyltransferase; Epigenomics; Histone code; Heterochromatin protein 1; Histone H3; Histone H2A; Heterochromatin; Histone; Chromatin remodeling; Chromatin; Genetics; Cell biology; DNA methylation; Methylation; Nucleosome; DNA; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002380609,0.0006487209,0.0008126519,0.001438754,0.000164964,0.0006412764,0.0006685762,0.0006346442,0.004831212],"category_scores_gemma":[0.0003531114,0.0001915535,0.0003049509,0.001364871,0.0002438021,0.0006935172,0.0004962268,0.001159879,0.003968913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004958336,"about_ca_system_score_gemma":0.0006390946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006011497,"about_ca_topic_score_gemma":0.0009418915,"domain_scores_codex":[0.9998801,0.00001455837,0.00001404634,0.00002719535,0.00004801403,0.00001599745],"domain_scores_gemma":[0.9998825,0.00003567431,0.00001937301,0.000004866825,0.00004081005,0.00001680084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009028953,0.00003804173,0.000171499,0.008451311,0.00006438889,0.0001552329,0.00002329135,0.0002994254,0.00458875,0.00287452,0.03083626,0.9524071],"study_design_scores_gemma":[0.000008347856,0.00004099937,0.0006000437,0.0008128004,0.00004357693,0.0007110106,0.00001517344,0.00005222474,0.001026937,0.001165094,0.995515,0.000008721804],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001659324,0.9969677,0.0002327646,0.0002336318,0.0002591415,0.000004401601,0.0000515851,0.00001871338,0.002066182],"genre_scores_gemma":[0.001322504,0.9958917,0.0002226448,0.0001877045,0.0001799368,0.000007462108,0.000115352,0.000003080916,0.002069612],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004831212,"threshold_uncertainty_score":0.01616204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152827508427759,"score_gpt":0.3053573720535718,"score_spread":0.2838290969692943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}