{"id":"W4311644750","doi":"10.3389/fmicb.2022.1011070","title":"Identification of antibodies cross-reactive with woodchuck immune cells and activation of virus-specific and global cytotoxic T cell responses by anti-PD-1 and anti-PD-L1 in experimental chronic hepatitis B and persistent occult hepadnaviral infection","year":2022,"lang":"en","type":"article","venue":"Frontiers in Microbiology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Memorial University of Newfoundland","funders":"","keywords":"Cytotoxic T cell; Woodchuck hepatitis virus; Immunology; Virology; Hepatitis B virus; Immune system; Antibody; T cell; Medicine; Antigen; Interferon; Biology; Virus; Hepadnaviridae; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001661485,0.000418475,0.0002103278,0.0002644458,0.0001404023,0.0001780865,0.0001209956,0.0003329853,0.001038013],"category_scores_gemma":[0.0001471288,0.0001415969,0.0002360514,0.0001075104,0.0001512763,0.0001605317,0.0001550885,0.0005484573,0.0001648764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002048467,"about_ca_system_score_gemma":0.0001119924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003391049,"about_ca_topic_score_gemma":0.0005039556,"domain_scores_codex":[0.9998108,0.00002789069,0.0000181319,0.00004029503,0.00002947651,0.00007357742],"domain_scores_gemma":[0.9999095,0.00001818072,0.00002027641,0.00001330605,0.00001355718,0.00002514178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002196042,0.000136027,0.0004893839,0.00002897381,0.000004980161,0.00004185878,0.00002392099,0.0000454956,0.9981091,0.00004118912,0.00001222344,0.000847114],"study_design_scores_gemma":[0.00008570845,0.005116843,0.01774158,0.00001108975,0.00005391873,0.0005668087,0.00005086389,0.0008565121,0.9741939,0.00006703196,0.001248852,0.000006957134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998801,0.0003036759,0.000453357,0.00001217245,0.000008157313,0.00002238825,0.00004637729,0.00001215609,0.0003406968],"genre_scores_gemma":[0.9980109,0.0002653976,0.0004465503,0.00003372865,0.00001037803,0.00005343943,0.0002114625,0.000004620264,0.0009635749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001038013,"threshold_uncertainty_score":0.003472507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008034343313984522,"score_gpt":0.2534787341765112,"score_spread":0.2454443908625266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}