{"id":"W4311649530","doi":"10.1007/s00726-022-03221-w","title":"Leucine ingestion promotes mTOR translocation to the periphery and enhances total and peripheral RPS6 phosphorylation in human skeletal muscle","year":2022,"lang":"en","type":"article","venue":"Amino Acids","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"mTORC1; Leucine; P70-S6 Kinase 1; Anabolism; Postprandial; PI3K/AKT/mTOR pathway; Ribosomal protein s6; Internal medicine; Mechanistic target of rapamycin; Endocrinology; Biology; Phosphorylation; Amino acid; Chemistry; Biochemistry; Signal transduction; Medicine; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002179911,0.00008782544,0.00008062088,0.000032113,0.000204269,0.00002553369,0.00005427712,0.00004089851,0.00002992963],"category_scores_gemma":[0.00001630587,0.00007915604,0.00001911171,0.00008244004,0.00004276557,0.00001116389,0.00005315364,0.00007475995,2.808929e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001358958,"about_ca_system_score_gemma":0.0000120268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007203969,"about_ca_topic_score_gemma":0.0001119682,"domain_scores_codex":[0.9993452,0.00008093494,0.0001258871,0.0002362073,0.00009652598,0.0001151981],"domain_scores_gemma":[0.9998022,0.000004734531,0.0000315908,0.0001113878,0.00001859075,0.00003149583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0000590979,0.00005443559,0.002077225,0.00001607273,0.000005504022,6.260889e-7,0.000972829,0.00006820458,0.90494,0.00006566932,0.00006739103,0.09167291],"study_design_scores_gemma":[0.001407218,0.001004082,0.7552002,0.00002017416,0.00002039934,0.00002609917,0.001026224,0.0005483332,0.221571,0.0001153117,0.01875528,0.000305674],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996286,0.002379303,0.0004363956,0.0004729979,0.0000904924,0.0002627541,0.0000114003,0.000007599442,0.00005309517],"genre_scores_gemma":[0.9990512,0.0001405339,0.0001540856,0.000105241,0.0001638595,0.0001250762,0.0001424493,0.000009629223,0.0001079577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.753123,"threshold_uncertainty_score":0.322789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007437242413065656,"score_gpt":0.2330011131785241,"score_spread":0.2255638707654585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}