{"id":"W4311649530","doi":"10.1007/s00726-022-03221-w","title":"Leucine ingestion promotes mTOR translocation to the periphery and enhances total and peripheral RPS6 phosphorylation in human skeletal muscle","year":2022,"lang":"en","type":"article","venue":"Amino Acids","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"mTORC1; Leucine; P70-S6 Kinase 1; Anabolism; Postprandial; PI3K/AKT/mTOR pathway; Ribosomal protein s6; Internal medicine; Mechanistic target of rapamycin; Endocrinology; Biology; Phosphorylation; Amino acid; Chemistry; Biochemistry; Signal transduction; Medicine; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463171,0.0002665033,0.0005010162,0.0002117892,0.0002618134,0.0003074486,0.0001107096,0.0001920503,0.002934798],"category_scores_gemma":[0.0001800047,0.000240058,0.0002923038,0.0001762119,0.0003380419,0.0002033886,0.0003062489,0.0004704438,0.0005130297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586922,"about_ca_system_score_gemma":0.0002469099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125771,"about_ca_topic_score_gemma":0.002953,"domain_scores_codex":[0.9998976,0.00003053233,0.000007401393,0.00002649297,0.0000112096,0.00002671449],"domain_scores_gemma":[0.9999022,0.00003153003,0.0000136717,0.00001207032,0.000008196722,0.00003223778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01694765,0.0001249063,0.001001383,0.0001098998,0.00002386181,0.0001414835,0.0000490451,0.00005052856,0.9781619,0.00003674423,0.0002403339,0.003112236],"study_design_scores_gemma":[0.0004402796,0.004039801,0.07217571,0.00002330683,0.0001109807,0.0006549445,0.0002515585,0.001155632,0.9187262,0.0001075169,0.002294729,0.00001930883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970472,0.00133336,0.0004477225,0.0001077552,0.00003611124,0.00001270996,0.0002275391,0.00005477934,0.0007327343],"genre_scores_gemma":[0.9955392,0.0003876548,0.0005051359,0.00006652028,0.00002937758,0.00002470254,0.0003804594,0.0000307546,0.003036074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002934798,"threshold_uncertainty_score":0.009817839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007437242413065656,"score_gpt":0.2330011131785241,"score_spread":0.2255638707654585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}