{"id":"W4311654287","doi":"10.1101/2022.12.05.22283131","title":"Efficacy of PD-(L)1 blockade monotherapy compared to PD-(L)1 blockade plus chemotherapy in first-line PD-L1-positive advanced lung adenocarcinomas: A cohort study","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Legend Biotech; EMD Serono; Genentech; National Institutes of Health; Daiichi Sankyo Europe; Sanofi; Kowa Company; Ipsen; Regeneron Pharmaceuticals; Natera; Memorial Sloan-Kettering Cancer Center; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Chemotherapy; Medicine; Internal medicine; Oncology; Blockade; Cohort; Retrospective cohort study; PD-L1; Propensity score matching; Proportional hazards model; Gastroenterology; Cancer; Immunotherapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002862107,0.000509347,0.0009249128,0.0004195817,0.0004303216,0.0009573199,0.0005600127,0.0005644517,0.001332874],"category_scores_gemma":[0.003977048,0.0003736688,0.002404458,0.0005854568,0.0003327083,0.0006386945,0.0004867509,0.001050586,0.0002549235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006240395,"about_ca_system_score_gemma":0.0009108849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001319187,"about_ca_topic_score_gemma":0.00137835,"domain_scores_codex":[0.9987344,0.0004138754,0.0001107706,0.0004569193,0.0001512477,0.0001328182],"domain_scores_gemma":[0.996561,0.0007787273,0.0013302,0.0005548619,0.0002375265,0.000537723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05023075,0.001723022,0.9248375,0.0001796325,0.005427765,0.000243293,0.0001759329,0.0006241616,0.002637026,0.0001013368,0.0007377219,0.01308199],"study_design_scores_gemma":[0.006140937,0.04240147,0.9335543,0.00007904217,0.007100185,0.001178428,0.0003459823,0.004687034,0.001956334,0.0002325852,0.002247989,0.00007565186],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984144,0.0006532744,0.0002244533,0.00003802861,0.00002067379,0.00004696023,0.0004816378,0.000005224117,0.0001151742],"genre_scores_gemma":[0.9986997,0.0002636447,0.0001617184,0.00005037082,0.00003663723,0.00004846928,0.0006263159,0.000004030731,0.0001089949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002862107,"threshold_uncertainty_score":0.01513648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01959244304615726,"score_gpt":0.3109771233776756,"score_spread":0.2913846803315184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}