{"id":"W4311660588","doi":"10.1152/physiol.00020.2022","title":"RANKL and RANK in Cancer Therapy","year":2022,"lang":"en","type":"review","venue":"Physiology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"T. Von Zastrow Foundation; Bundesministerium für Bildung, Wissenschaft und Forschung; Austrian Science Fund; Österreichischen Akademie der Wissenschaften; Canada Research Chairs","keywords":"RANKL; Immune system; Activator (genetics); RANK Ligand; Receptor; Biology; Cancer; Immunology; Cancer research; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006603064,0.000220683,0.0007166205,0.00005550083,0.00003761099,0.000005039324,0.000164519,0.0001615755,0.0003114959],"category_scores_gemma":[0.00002011914,0.0001761519,0.0001701684,0.00008567292,0.00007308512,0.00000104432,0.0001656061,0.0001372152,0.000004045658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007363054,"about_ca_system_score_gemma":0.0001542039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008460078,"about_ca_topic_score_gemma":0.0000172155,"domain_scores_codex":[0.9989066,0.0002386274,0.0001939691,0.0004220791,0.00004296389,0.0001957339],"domain_scores_gemma":[0.9995701,0.00002651238,0.00008928248,0.0002632736,0.000006963407,0.00004390287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005564437,0.00006427774,0.00001180707,0.0008245698,0.00007756393,0.000002354321,0.000007842393,9.524272e-7,0.0009381558,0.00003163505,0.001470883,0.9965143],"study_design_scores_gemma":[0.0003858728,0.00005111519,0.0002339925,0.00007747968,0.00005723617,0.000004225087,0.000003202322,2.48942e-7,0.0000182726,0.00006495338,0.9989125,0.0001909141],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00214971,0.9969884,3.478166e-7,0.000009388241,0.0003027954,0.0002685501,0.00009791544,0.000005351571,0.0001776019],"genre_scores_gemma":[0.0002025269,0.9981098,0.000005309419,0.0002329138,0.0003005614,0.0004467643,0.000429388,0.00002925351,0.0002434667],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9974416,"threshold_uncertainty_score":0.7183265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05341453845394691,"score_gpt":0.3546788998724221,"score_spread":0.3012643614184752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}