{"id":"W4311662347","doi":"10.1016/j.cell.2022.11.004","title":"Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer","year":2022,"lang":"en","type":"article","venue":"Cell","topic":"Wound Healing and Treatments","field":"Medicine","cited_by":166,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; Ontario Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Calgary Firefighters Burn Treatment Society","keywords":"Biology; Scars; Fibroblast; Immune system; Wound healing; Fibrosis; Regeneration (biology); Skin repair; Human skin; Pathology; Phenotype; Dermis; Cell biology; Inflammation; Immunology; SNAI1; Anatomy; Cell culture; Medicine; Gene; Epithelial–mesenchymal transition; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002977801,0.0003894525,0.0003663379,0.0003696638,0.0004937617,0.0006163747,0.0003037612,0.000851768,0.004362314],"category_scores_gemma":[0.0001987491,0.0001889585,0.0003626827,0.0001086012,0.0006486449,0.000499347,0.0004224445,0.001040125,0.0006716247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002127676,"about_ca_system_score_gemma":0.0001895084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005783417,"about_ca_topic_score_gemma":0.001641248,"domain_scores_codex":[0.999817,0.00003067896,0.000008069978,0.00003806911,0.00002523611,0.00008097373],"domain_scores_gemma":[0.9998732,0.00002512843,0.00002302128,0.00002488135,0.00001295638,0.00004075671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008130303,0.0002301252,0.001461744,0.00003618563,0.000006680455,0.000255254,0.0001473467,0.00006239742,0.9938793,0.000620809,0.0001198783,0.002367291],"study_design_scores_gemma":[0.0001491799,0.004939593,0.06632061,0.0001048503,0.000105376,0.002469504,0.002383986,0.001730745,0.9144392,0.0007947508,0.006512449,0.00004960012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979975,0.0005675958,0.0003219071,0.00006918491,0.00003229374,0.00001900996,0.00004370693,0.00001504486,0.0009338401],"genre_scores_gemma":[0.9945366,0.0003704127,0.0006596812,0.00009184967,0.00001224903,0.00002846828,0.0001124964,0.0000135224,0.004174812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004362314,"threshold_uncertainty_score":0.01459342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02334248669820966,"score_gpt":0.2694515490237356,"score_spread":0.246109062325526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}