{"id":"W4311668214","doi":"10.1016/j.immuni.2022.11.003","title":"Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development","year":2022,"lang":"en","type":"article","venue":"Immunity","topic":"Infant Nutrition and Health","field":"Nursing","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; McMaster University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ministère de l’Éducation, Gouvernement de l’Ontario; National Research Foundation of Korea; University of Toronto","keywords":"Paneth cell; Biology; Stem cell; Mesenchymal stem cell; Wnt signaling pathway; Necrotizing enterocolitis; Cell biology; Cellular differentiation; Stem cell niche; Immunology; Organoid; Gut flora; Cell; Microbiology; Progenitor cell; Signal transduction; Small intestine; Internal medicine; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002736969,0.0002507061,0.0002952745,0.0005030962,0.000244832,0.0005508977,0.000182116,0.0003305603,0.001887196],"category_scores_gemma":[0.0003121105,0.0002065341,0.0002528749,0.0001719638,0.000285899,0.0002708099,0.0005305674,0.0008683524,0.0003467936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002657819,"about_ca_system_score_gemma":0.0004702803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000870175,"about_ca_topic_score_gemma":0.003316663,"domain_scores_codex":[0.9997713,0.00004519931,0.00001244508,0.00003011515,0.00006085539,0.00008014293],"domain_scores_gemma":[0.9997315,0.00004114942,0.00005001906,0.00001273372,0.00005052703,0.0001140412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001088596,0.00009284212,0.006260822,0.0001008469,0.000009742997,0.0005432821,0.0003050927,0.00006312249,0.9753547,0.0008788728,0.0001981406,0.01510384],"study_design_scores_gemma":[0.00007774247,0.001382689,0.1830213,0.0001889857,0.00008503105,0.001067358,0.002192409,0.001013411,0.7992197,0.0009537083,0.01077509,0.00002257095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907705,0.002923764,0.002730667,0.00011817,0.00004809923,0.00002068111,0.0001954155,0.0000590804,0.003133653],"genre_scores_gemma":[0.9887389,0.002032782,0.00216106,0.00008014216,0.00002556016,0.00005302218,0.0001858789,0.00004093557,0.006681584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001887196,"threshold_uncertainty_score":0.006313324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0186095698265971,"score_gpt":0.2521196029837498,"score_spread":0.2335100331571527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}