{"id":"W4311668214","doi":"10.1016/j.immuni.2022.11.003","title":"Gut microbiota promotes stem cell differentiation through macrophage and mesenchymal niches in early postnatal development","year":2022,"lang":"en","type":"article","venue":"Immunity","topic":"Infant Nutrition and Health","field":"Nursing","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; McMaster University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ministère de l’Éducation, Gouvernement de l’Ontario; National Research Foundation of Korea; University of Toronto","keywords":"Paneth cell; Biology; Stem cell; Mesenchymal stem cell; Wnt signaling pathway; Necrotizing enterocolitis; Cell biology; Cellular differentiation; Stem cell niche; Immunology; Organoid; Gut flora; Cell; Microbiology; Progenitor cell; Signal transduction; Small intestine; Internal medicine; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002742444,0.0001176947,0.0001520284,0.00009183664,0.0005964951,0.00004664885,0.0001333686,0.00005070806,0.0001016797],"category_scores_gemma":[0.000005182108,0.0001280196,0.00002534404,0.0001599613,0.00003404353,0.0001379904,0.0001839023,0.0004501011,0.00001117048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002022394,"about_ca_system_score_gemma":0.00004226282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007366312,"about_ca_topic_score_gemma":0.00007318373,"domain_scores_codex":[0.9988509,0.0003152381,0.0002668744,0.000169815,0.0001462004,0.0002509431],"domain_scores_gemma":[0.9996286,0.00005058203,0.00009114722,0.0001670232,0.00002718644,0.00003545414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00130966,0.002500056,0.07568016,0.0009561794,0.00004336927,0.00008343867,0.1481454,0.000007202669,0.7555546,0.0003749166,0.001083335,0.01426177],"study_design_scores_gemma":[0.001536117,0.0002285781,0.9173111,0.00003885741,0.000007895381,0.00003913619,0.002291426,0.00004890346,0.07558233,0.0001010023,0.002582367,0.000232338],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978704,0.0005778382,0.00001089684,0.000456979,0.0002751222,0.0003471823,0.00004444421,0.00004452188,0.0003725773],"genre_scores_gemma":[0.9988011,0.00001334944,0.0006231206,0.0002370695,0.00001616167,0.00002516536,0.0001004751,0.00001475699,0.0001688514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8416309,"threshold_uncertainty_score":0.5220488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0186095698265971,"score_gpt":0.2521196029837498,"score_spread":0.2335100331571527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}