{"id":"W4311675501","doi":"10.1038/s41467-022-35131-6","title":"Structure of the AlgKX modification and secretion complex required for alginate production and biofilm attachment in Pseudomonas aeruginosa","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Agriculture and Agri-Food Canada; Université de Montréal; University of Alberta; SickKids Foundation; University of Toronto","funders":"Canadian Glycomics Network; Hospital for Sick Children; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Canada Excellence Research Chairs, Government of Canada; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Canada Research Chairs; Canadian Institutes of Health Research; Sick Kids Foundation; Government of Canada; Canadian Light Source","keywords":"Biofilm; Pseudomonas aeruginosa; Secretion; Peptidoglycan; Biosynthesis; Bacteria; Bacterial outer membrane; Biochemistry; Chemistry; Microbiology; Cell biology; Biology; Cell wall; Enzyme; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001301394,0.0003250799,0.0003960014,0.0001708811,0.0005193534,0.0007527748,0.0004155686,0.0004841669,0.001195022],"category_scores_gemma":[0.0003770679,0.000295466,0.0002546772,0.0002794202,0.0003912997,0.0003825783,0.0003377672,0.0008967402,0.0004044587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001540051,"about_ca_system_score_gemma":0.0009075869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005646292,"about_ca_topic_score_gemma":0.005071416,"domain_scores_codex":[0.9998822,0.00001304576,0.000008378531,0.00002313912,0.00005293874,0.00002026952],"domain_scores_gemma":[0.9997994,0.00002488901,0.000046487,0.00001484941,0.00002529861,0.00008905961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003391156,0.0001190792,0.00195873,0.0001383682,0.0000278846,0.0007796917,0.0001851247,0.002159879,0.9896829,0.001596168,0.0007443944,0.002268763],"study_design_scores_gemma":[0.0003865054,0.0007464049,0.1352534,0.00009583182,0.00008304562,0.002457507,0.0008820728,0.06321982,0.7773336,0.002027738,0.01731727,0.0001970061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958547,0.000736145,0.001439847,0.000318726,0.00003868986,0.00001659772,0.0003117317,0.00007135326,0.001212141],"genre_scores_gemma":[0.9927771,0.0003475007,0.003052175,0.0001896663,0.00001588185,0.00002120233,0.001554199,0.00003636506,0.002006003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005646292,"threshold_uncertainty_score":0.01122683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02471165702472816,"score_gpt":0.2943231854147462,"score_spread":0.2696115283900181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}