{"id":"W4311677544","doi":"10.3390/ijms232315410","title":"Revisiting the Anti-Cancer Toxicity of Clinically Approved Platinating Derivatives","year":2022,"lang":"en","type":"review","venue":"International Journal of Molecular Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Ovarian Cancer Canada; McGill University","keywords":"DNA damage; Cisplatin; Cell biology; Endoplasmic reticulum; Mitochondrion; Apoptosis; Cancer cell; Oxaliplatin; Programmed cell death; Unfolded protein response; DNA repair; Biology; Chemistry; Cancer research; Cancer; DNA; Biochemistry; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002580151,0.0001917929,0.0005585245,0.0001371911,0.0001078327,0.00006745445,0.002000492,0.00009773089,0.0000654695],"category_scores_gemma":[0.001387862,0.0001260281,0.0006325513,0.0002122778,0.0002652716,0.00001250699,0.0005398437,0.000319391,4.579219e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003676249,"about_ca_system_score_gemma":0.0006086132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003060985,"about_ca_topic_score_gemma":3.758838e-7,"domain_scores_codex":[0.9970138,0.000413317,0.001194121,0.0002822541,0.0009430991,0.0001534128],"domain_scores_gemma":[0.9964954,0.0002051249,0.002751931,0.0001850487,0.0003211201,0.00004140812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001472127,0.00004755664,0.0000496185,0.0002967154,0.0005627667,0.0000280227,0.00005984902,0.0002452991,0.04260231,0.0004452752,0.00003212763,0.9556158],"study_design_scores_gemma":[0.0004001882,0.000652045,0.00001075257,0.003993284,0.0003154915,0.0005068802,0.0004432953,0.0001290137,0.05003413,0.000317098,0.9427331,0.0004647004],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01457516,0.9809185,0.002711206,0.0001927,0.0007460334,0.0001937797,0.00003170086,0.000003453302,0.0006274584],"genre_scores_gemma":[0.008333569,0.9861532,0.004779493,0.0001613147,0.0004896399,0.00001384717,0.00001124324,0.00001991886,0.00003772421],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.955151,"threshold_uncertainty_score":0.5139278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05802452133153729,"score_gpt":0.390497115943407,"score_spread":0.3324725946118697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}