{"id":"W4311708185","doi":"10.1093/bjs/znac404.035","title":"OGC O03 Patient-derived oesophageal adenocarcinoma organoids may predict response to induction therapies in oesophageal cancer","year":2022,"lang":"en","type":"article","venue":"British journal of surgery","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Medicine; Irinotecan; Internal medicine; Paclitaxel; Oncology; Organoid; Neoadjuvant therapy; Adenocarcinoma; Cancer; Cisplatin; Taxane; Complete response; Gastroenterology; Chemotherapy; Colorectal cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004657983,0.0002333865,0.0003610804,0.0005597349,0.0001644432,0.0007533158,0.0001504714,0.0003821571,0.001678944],"category_scores_gemma":[0.000832106,0.0001312518,0.0002264069,0.0004255768,0.0001702212,0.0002246583,0.0003646186,0.0003215987,0.0005675956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003056407,"about_ca_system_score_gemma":0.0001116761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001413832,"about_ca_topic_score_gemma":0.001362318,"domain_scores_codex":[0.9998043,0.00004524237,0.00002377471,0.0000603408,0.00003799543,0.000028438],"domain_scores_gemma":[0.9994548,0.0001478445,0.0001235886,0.00005584335,0.00009618777,0.0001217641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002562099,0.00009995995,0.8735151,0.00008855336,0.00007521491,0.0002434355,0.0001648786,0.001324815,0.1092978,0.00004292795,0.0005275138,0.0120578],"study_design_scores_gemma":[0.00003798208,0.001194623,0.961843,0.0000181984,0.00008828891,0.001087143,0.000349169,0.005014967,0.02811961,0.00007237308,0.002159221,0.00001554894],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976863,0.0003100522,0.0005716049,0.00002283781,0.000005414575,0.00001723476,0.0008393735,0.00002786909,0.0005192737],"genre_scores_gemma":[0.9976391,0.00007381096,0.0005506846,0.00001723413,0.000002971216,0.0000172721,0.001441168,0.000006975007,0.0002508901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001678944,"threshold_uncertainty_score":0.005616605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03119626654008499,"score_gpt":0.2900899139603181,"score_spread":0.2588936474202331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}