{"id":"W4311738729","doi":"10.1093/ofid/ofac492.1897","title":"LB2307. Safety and Efficacy of Letermovir (LET) versus Valganciclovir (VGCV) for Prevention of Cytomegalovirus (CMV) Disease in Kidney Transplant Recipients (KTRs): A Phase 3 Randomized Study","year":2022,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Valganciclovir; Immunosuppression; Internal medicine; Clinical endpoint; Gastroenterology; Renal function; Chemoprophylaxis; Randomized controlled trial; Cytomegalovirus; Kidney disease; Immunology; Ganciclovir; Human cytomegalovirus; Virus; Viral disease; Herpesviridae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001914432,0.001399093,0.003105461,0.0003855145,0.0003800986,0.001561422,0.001096557,0.001686425,0.01118167],"category_scores_gemma":[0.001710735,0.0006540237,0.001829944,0.0004770719,0.001056688,0.00106546,0.0003866378,0.003202708,0.001930166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007475241,"about_ca_system_score_gemma":0.001547257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008085631,"about_ca_topic_score_gemma":0.001723757,"domain_scores_codex":[0.9989586,0.0006239574,0.00005780767,0.0001449133,0.00008367316,0.0001311055],"domain_scores_gemma":[0.9989194,0.0002939707,0.0002521044,0.00006954002,0.00007567555,0.0003894305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9760099,0.007383574,0.0001808129,0.000485463,0.0006770096,0.0000197495,0.00001715416,0.0002243892,0.002760053,0.00007619795,0.0007911777,0.01137461],"study_design_scores_gemma":[0.8618641,0.1354285,0.0006742874,0.00004129908,0.000460575,0.00002497958,0.00001258117,0.0003792129,0.0004785625,0.0001229714,0.0004965115,0.00001638465],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745688,0.008255568,0.001102018,0.001014064,0.0008834045,0.006148577,0.003137879,0.0003967511,0.004492909],"genre_scores_gemma":[0.9859825,0.002453458,0.001559759,0.001127279,0.0003987687,0.004558051,0.001087175,0.00004132794,0.002791673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01118167,"threshold_uncertainty_score":0.03740644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893970349500108,"score_gpt":0.3590225334621284,"score_spread":0.3300828299671273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}