{"id":"W4311738729","doi":"10.1093/ofid/ofac492.1897","title":"LB2307. Safety and Efficacy of Letermovir (LET) versus Valganciclovir (VGCV) for Prevention of Cytomegalovirus (CMV) Disease in Kidney Transplant Recipients (KTRs): A Phase 3 Randomized Study","year":2022,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Valganciclovir; Immunosuppression; Internal medicine; Clinical endpoint; Gastroenterology; Renal function; Chemoprophylaxis; Randomized controlled trial; Cytomegalovirus; Kidney disease; Immunology; Ganciclovir; Human cytomegalovirus; Virus; Viral disease; Herpesviridae","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001285776,0.0003552231,0.001533794,0.0006082207,0.0003698633,0.00006160135,0.0003814816,0.00006186369,0.0004924053],"category_scores_gemma":[0.001100949,0.0003285033,0.000530208,0.0006810509,0.0003059148,0.0002977391,0.0004615306,0.0002921403,0.000004053913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003057812,"about_ca_system_score_gemma":0.0007420957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001304276,"about_ca_topic_score_gemma":0.0002264556,"domain_scores_codex":[0.9961815,0.0006759377,0.00114976,0.0006937479,0.0007464035,0.0005526442],"domain_scores_gemma":[0.9972888,0.0008923372,0.0004173422,0.0005938554,0.0001599197,0.0006477836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8156746,0.01851671,0.1472453,0.0004690775,0.0008766627,0.0001045629,0.000993069,0.0001280112,0.000623645,0.0003902638,0.0003728625,0.0146052],"study_design_scores_gemma":[0.8999791,0.01034351,0.07995469,0.0004456862,0.002028063,0.00001417068,0.0005909459,0.00154703,0.00034663,0.0005251443,0.00369395,0.0005310716],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9834749,0.0006149794,0.0001531409,0.0002187155,0.000262939,0.01194857,0.002335889,0.00004334106,0.0009475838],"genre_scores_gemma":[0.9968406,0.0002482697,0.00002791682,0.000130077,0.00003739385,0.00182438,0.0004981107,0.00006492422,0.000328304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08430452,"threshold_uncertainty_score":0.9999167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02893970349500108,"score_gpt":0.3590225334621284,"score_spread":0.3300828299671273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}