{"id":"W4311774295","doi":"10.1016/j.heliyon.2022.e12380","title":"New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice","year":2022,"lang":"en","type":"article","venue":"Heliyon","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Fonds de Recherche du Québec - Santé; Université du Québec à Montréal; Université de Montréal; McGill University Health Centre; Concordia University of Edmonton","funders":"Canadian Institutes of Health Research; Genentech; IXICO; H. Lundbeck A/S; Servier; Direktion für Entwicklung und Zusammenarbeit; Centre d'Imagerie BioMédicale; Centre Hospitalier Universitaire Vaudois; Université de Genève; Eisai; Courtois Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; McGill University Health Centre; Centre d’Excellence en Recherche sur les Maladies Orphelines – Fondation Courtois; Northern California Institute for Research and Education; Alzheimer's Association; Hôpitaux Universitaires de Genève; F. Hoffmann-La Roche; R. Howard Webster Foundation; University of Southern California; Pfizer; Biogen; BioClinica; Université de Lausanne; Novartis Pharmaceuticals Corporation; École Polytechnique Fédérale de Lausanne; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; National Science Foundation","keywords":"Chagas disease; Trypanosoma cruzi; Metabolomics; Pathogenesis; Metabolome; Biology; Disease; Immunology; Internal medicine; Physiology; Bioinformatics; Medicine; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004038076,0.00008043738,0.0001480919,0.0001404497,0.0001430241,0.00001941784,0.00006554749,0.00002810973,0.0004415056],"category_scores_gemma":[0.0001391471,0.00007566034,0.00004358078,0.0001968272,0.00001794158,0.00006983453,0.0000611184,0.000193798,0.000006772898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004699549,"about_ca_system_score_gemma":0.0001221926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000140925,"about_ca_topic_score_gemma":0.00002344673,"domain_scores_codex":[0.9991649,0.00004443244,0.0001403066,0.0002296353,0.0002118938,0.0002088781],"domain_scores_gemma":[0.9994308,0.00006464549,0.00003175554,0.0002052411,0.00003739563,0.0002301981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001653858,0.0006204005,0.02676073,0.001276218,0.00009927603,0.00004201963,0.002919548,0.00003203364,0.8301046,0.02062892,0.0698173,0.04604505],"study_design_scores_gemma":[0.001914212,0.0002467216,0.6214516,0.0000543899,0.00003792392,0.000009472979,0.0003398364,0.0000722713,0.0009246633,0.000732807,0.3741035,0.0001125912],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9223556,0.04666655,0.0008866405,0.0253918,0.0001155886,0.002384107,0.0004070307,0.00007137242,0.001721349],"genre_scores_gemma":[0.9336396,0.001865539,0.0008089081,0.002514735,0.0003076421,0.0005490108,0.0004021946,0.00003379841,0.05987858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8291799,"threshold_uncertainty_score":0.4834177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397351194544094,"score_gpt":0.3065582617679107,"score_spread":0.2825847498224698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}