{"id":"W4311774295","doi":"10.1016/j.heliyon.2022.e12380","title":"New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice","year":2022,"lang":"en","type":"article","venue":"Heliyon","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Fonds de Recherche du Québec - Santé; Université du Québec à Montréal; Université de Montréal; McGill University Health Centre; Concordia University of Edmonton","funders":"Canadian Institutes of Health Research; Genentech; IXICO; H. Lundbeck A/S; Servier; Direktion für Entwicklung und Zusammenarbeit; Centre d'Imagerie BioMédicale; Centre Hospitalier Universitaire Vaudois; Université de Genève; Eisai; Courtois Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; McGill University Health Centre; Centre d’Excellence en Recherche sur les Maladies Orphelines – Fondation Courtois; Northern California Institute for Research and Education; Alzheimer's Association; Hôpitaux Universitaires de Genève; F. Hoffmann-La Roche; R. Howard Webster Foundation; University of Southern California; Pfizer; Biogen; BioClinica; Université de Lausanne; Novartis Pharmaceuticals Corporation; École Polytechnique Fédérale de Lausanne; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; National Science Foundation","keywords":"Chagas disease; Trypanosoma cruzi; Metabolomics; Pathogenesis; Metabolome; Biology; Disease; Immunology; Internal medicine; Physiology; Bioinformatics; Medicine; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001047213,0.0003285884,0.0002123929,0.0009282309,0.0001707161,0.0002814552,0.00008500399,0.0002142854,0.001793359],"category_scores_gemma":[0.00009828339,0.0001189586,0.0001792398,0.0003939068,0.0001971111,0.0001115374,0.000216541,0.0003367309,0.000203375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001234532,"about_ca_system_score_gemma":0.00009933396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004346003,"about_ca_topic_score_gemma":0.0007337491,"domain_scores_codex":[0.9999263,0.00001233042,0.000004083432,0.00002536357,0.00001583535,0.0000160631],"domain_scores_gemma":[0.9999335,0.000006440923,0.00002466175,0.000006126753,0.000006369467,0.00002294365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009581692,0.00003572325,0.02065449,0.00005875495,0.00005494959,0.0004604226,0.00004681192,0.00002624396,0.9704773,0.0001262434,0.0002203716,0.006880431],"study_design_scores_gemma":[0.00004523423,0.0007846745,0.8464677,0.00002851508,0.0001294948,0.00807051,0.0002554266,0.0005944896,0.1371963,0.0005190423,0.005882352,0.00002614777],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897588,0.003259562,0.002999299,0.0002297631,0.00003792402,0.00002329449,0.002027607,0.0001010504,0.001562758],"genre_scores_gemma":[0.9942098,0.001318885,0.001610243,0.0001531714,0.00002021023,0.00002147629,0.001705041,0.00002305175,0.0009380511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793359,"threshold_uncertainty_score":0.005999386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02397351194544094,"score_gpt":0.3065582617679107,"score_spread":0.2825847498224698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}