{"id":"W4311784836","doi":"10.7554/elife.78609","title":"Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; University of Toronto; Norges Forskningsråd; Boehringer Ingelheim Fonds; Ragon Institute of MGH, MIT and Harvard; International Anesthesia Research Society","keywords":"Pyroptosis; Programmed cell death; Cell biology; Apoptosis; Glycine; Cytoprotection; Biology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001917923,0.0001855128,0.0001854618,0.00009837912,0.0001291132,0.00001905616,0.0002900516,0.00009059021,0.0002154333],"category_scores_gemma":[0.00003395675,0.0002007845,0.00007503236,0.0001776011,0.00001503076,0.000005300074,0.0005054655,0.0002112677,0.00002888465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002572606,"about_ca_system_score_gemma":0.00005386073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005999206,"about_ca_topic_score_gemma":0.0001317648,"domain_scores_codex":[0.9987221,0.00007164494,0.0002526523,0.0003693546,0.0002204233,0.0003638719],"domain_scores_gemma":[0.9994835,0.000008284042,0.00005151602,0.0003440412,0.00003466508,0.0000780227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003370324,0.00009263989,0.0009791572,0.00003515257,0.00001709313,0.00002011878,0.0003847328,0.01204963,0.9825174,0.000006269062,0.003273875,0.000286958],"study_design_scores_gemma":[0.001404616,0.0002985523,0.0005739664,0.000008551207,0.000006437053,0.00001699526,0.0004772257,0.0003230807,0.8394805,0.000001285966,0.1571502,0.0002586042],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941489,0.0004782616,0.00004618009,0.000419705,0.0002780623,0.0002701935,0.0000335674,0.00001757679,0.004307561],"genre_scores_gemma":[0.9942051,0.00008816447,0.0002394929,0.001413867,0.0001204039,0.00008976494,0.0002558898,0.00003759596,0.00354978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1538763,"threshold_uncertainty_score":0.8187755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007107950906094051,"score_gpt":0.2216974876717467,"score_spread":0.2145895367656526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}