{"id":"W4311785325","doi":"10.3390/curroncol29120756","title":"CDK4/6 Inhibitors as Upfront Treatment in a Patient with Breast Cancer Presenting with a Clinical Critic Situation: A Case Report and Review of the Literature","year":2022,"lang":"en","type":"review","venue":"Current Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Metastatic breast cancer; Letrozole; Breast cancer; Chemotherapy; Clinical trial; Cancer; Oncology; Population; Intensive care medicine; Internal medicine; Tamoxifen","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002960652,0.0006745973,0.0009456393,0.001963982,0.00039586,0.0009267185,0.0006502226,0.001511005,0.001383872],"category_scores_gemma":[0.001244064,0.0002681958,0.0005627148,0.001751317,0.0004648281,0.00120847,0.0003861654,0.001321686,0.000632042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003699748,"about_ca_system_score_gemma":0.000638585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007105769,"about_ca_topic_score_gemma":0.002068372,"domain_scores_codex":[0.9997805,0.00004540524,0.00005477006,0.00003700796,0.00005589693,0.00002636509],"domain_scores_gemma":[0.999589,0.0002298398,0.00009923719,0.00001245052,0.00003623877,0.00003317512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.0001680284,0.000154867,0.006773374,0.01830724,0.0003369373,0.4548985,0.0007310606,0.0006844637,0.003971307,0.002034546,0.03465599,0.4772837],"study_design_scores_gemma":[0.00002157644,0.00008709765,0.0038073,0.004811655,0.0003537153,0.8433,0.0004681284,0.0002123467,0.0008296712,0.0008456161,0.1452195,0.00004332771],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004166209,0.9911369,0.000470362,0.001175185,0.0003807595,0.00001755634,0.00003360801,0.00001487545,0.002604564],"genre_scores_gemma":[0.03951597,0.9556084,0.0008814191,0.001814081,0.001105069,0.00001252114,0.00008605664,0.000008505765,0.0009679392],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001963982,"threshold_uncertainty_score":0.004629493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1118065257088097,"score_gpt":0.4815901247787339,"score_spread":0.3697835990699242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}