{"id":"W4311829981","doi":"10.1101/2022.12.14.516867","title":"Expression of substance P, NPY and their Receptors Is Altered in Major Depression","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institutes of Health; Marcus och Amalia Wallenbergs minnesfond; Fondation Brain Canada; Knut och Alice Wallenbergs Stiftelse; Parkinsonfonden; Hjärnfonden; Magyar Tudományos Akadémia; Science for Life Laboratory; Vetenskapsrådet; Semmelweis Egyetem; Svenska Sällskapet för Medicinsk Forskning; National Alliance for Research on Schizophrenia and Depression; Canadian Institutes of Health Research; AFA Försäkring; Karolinska Institutet","keywords":"Dorsal raphe nucleus; Neuropeptide Y receptor; Internal medicine; Endocrinology; Dorsolateral prefrontal cortex; Substance P; Tachykinin receptor; Locus coeruleus; Neuropeptide; Receptor; Raphe nuclei; Galanin; Biology; Mood disorders; Serotonin; Prefrontal cortex; Medicine; Psychology; Central nervous system; Neuroscience; Serotonergic; Psychiatry; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006851474,0.0001226307,0.0001512345,0.0001991404,0.0001278135,0.0002315723,0.000071241,0.0001627302,0.001178746],"category_scores_gemma":[0.0001766028,0.000122491,0.0001322131,0.0001397777,0.000120464,0.00005072408,0.0001143302,0.0002429911,0.0002223258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000147927,"about_ca_system_score_gemma":0.0000748154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384976,"about_ca_topic_score_gemma":0.002171507,"domain_scores_codex":[0.9999356,0.000007212248,0.000004648201,0.00002650389,0.0000125957,0.0000133183],"domain_scores_gemma":[0.999929,0.000007473071,0.00003316274,0.000004809807,0.00001255175,0.00001312537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001845243,0.00006211307,0.1621099,0.000244017,0.0002280605,0.0007091337,0.0003244547,0.0001556184,0.8123726,0.0001040819,0.0009291933,0.02091563],"study_design_scores_gemma":[0.00001409727,0.0001304062,0.9871249,0.00001700958,0.00006057708,0.0008377051,0.0001277939,0.0001948635,0.01055456,0.00007933683,0.0008541231,0.000004733113],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967722,0.0009778984,0.0004349262,0.00005370299,0.00001023147,0.000009584861,0.001215571,0.00001662247,0.0005093194],"genre_scores_gemma":[0.9975521,0.0005108498,0.0003389838,0.00007295643,0.00000693122,0.00001653189,0.0007186471,0.000009165123,0.0007738768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384976,"threshold_uncertainty_score":0.003943264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02367245359829259,"score_gpt":0.2324772831875661,"score_spread":0.2088048295892735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}