{"id":"W4311842546","doi":"10.1101/2022.12.07.519468","title":"Gremlin 1 is required for macrophage M2 polarization","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre","funders":"","keywords":"Paracrine signalling; Autocrine signalling; Macrophage polarization; Pulmonary fibrosis; Fibrosis; Cell biology; Recombinant DNA; Interleukin 4; Macrophage; Biology; Immunology; Cancer research; Medicine; Pathology; Cytokine; In vitro; Cell culture; Receptor; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007483879,0.0007576257,0.0007869751,0.0004288056,0.000718898,0.0001619214,0.0008958238,0.001222169,0.004450539],"category_scores_gemma":[0.0003981416,0.0008844464,0.0003976327,0.0004325372,0.0002048251,0.0001848129,0.0008006472,0.001267095,0.0004857358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004964817,"about_ca_system_score_gemma":0.000703689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007805193,"about_ca_topic_score_gemma":0.000002783742,"domain_scores_codex":[0.9961376,0.0004346452,0.0009439248,0.001493469,0.0001716896,0.0008187367],"domain_scores_gemma":[0.9967026,0.0001620729,0.0008248779,0.001643395,0.0005581239,0.000108958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001468031,0.0001703323,0.001859403,0.0003168246,0.0003274513,0.00001670818,0.00005254882,0.00002054988,0.9828292,0.0006704502,0.01358648,0.000003291467],"study_design_scores_gemma":[0.001523338,0.0001466275,0.007241947,0.00009328499,0.0001996584,4.598673e-8,0.000009941083,0.00006438058,0.8027807,0.000005879952,0.1869545,0.0009796622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9531051,0.007677814,0.01075625,0.000718176,0.01332233,0.003915123,0.009221468,0.001256,0.00002775485],"genre_scores_gemma":[0.9940358,0.000087893,0.002381472,0.0008465543,0.0004445194,0.001134809,0.0000312141,0.0002505394,0.0007871551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1800485,"threshold_uncertainty_score":0.9993606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01679675962467636,"score_gpt":0.2353401836037855,"score_spread":0.2185434239791091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}