{"id":"W4311844929","doi":"10.1136/jcp-2022-208461","title":"Gene of the month: PALB2","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Pathology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"PALB2; RAD51; BRCA2 Protein; Genetics; Homologous recombination; Biology; Gene; DNA repair; Germline; Germline mutation; Mutation; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001338811,0.00005615374,0.0002249291,0.00002584563,0.0000619826,0.000001907973,0.0004114599,0.00008878858,0.00008946665],"category_scores_gemma":[0.0007592929,0.00004004426,0.000311784,0.00008166942,0.0001750552,0.000001305509,0.0002705713,0.0003304621,0.000001012523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001699547,"about_ca_system_score_gemma":0.0003499791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000100564,"about_ca_topic_score_gemma":0.000003494963,"domain_scores_codex":[0.9983337,0.0004862713,0.0007965636,0.0001162433,0.0001717045,0.00009550539],"domain_scores_gemma":[0.9986845,0.00008341829,0.000748492,0.0002997236,0.0001463961,0.00003749757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001628033,0.001104537,0.1861399,0.00002041109,0.0004619334,0.0001823431,0.0003150707,0.01064538,0.6757928,0.0002896644,0.07389523,0.04952469],"study_design_scores_gemma":[0.005107543,0.00583853,0.3433973,0.00001305199,0.0002222737,0.002835628,0.0004562055,0.00006727633,0.168132,0.003977539,0.4696448,0.0003078651],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946452,0.00104023,0.0003247916,0.001382432,0.002024303,0.00005219531,0.00001856557,8.515607e-7,0.000511439],"genre_scores_gemma":[0.9965402,0.0001466594,0.001475322,0.001028217,0.0005137911,0.000003975473,0.000002512134,0.000009066905,0.00028028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5076608,"threshold_uncertainty_score":0.1632957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04233691050547646,"score_gpt":0.374975305092911,"score_spread":0.3326383945874345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}