{"id":"W4311852494","doi":"10.3390/antibiotics11121768","title":"Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance","year":2022,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Université de Montréal; PROTEO; Centre in Green Chemistry and Catalysis","funders":"Université de Montréal; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Antibiotic resistance; Antibiotics; Trimethoprim; Biology; Dihydrofolate reductase; Drug resistance; Genetics; Microbiology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006051749,0.0003844822,0.0004696345,0.0002414254,0.0002600031,0.00003640909,0.0006167477,0.000178619,0.0000414688],"category_scores_gemma":[0.0001545149,0.0004330316,0.0001593973,0.0004555583,0.0002874168,0.00005055939,0.0006673388,0.0002945394,0.000008149771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002110203,"about_ca_system_score_gemma":0.0001554157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005221753,"about_ca_topic_score_gemma":0.00005848161,"domain_scores_codex":[0.9967737,0.0004600156,0.000748873,0.0009354305,0.0004846278,0.0005973767],"domain_scores_gemma":[0.9984744,0.00006534252,0.0003536052,0.0009304525,0.00003227821,0.0001439331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001346841,0.0006423978,0.05683658,0.00007153542,0.00006859337,0.0001139859,0.0001600351,0.000593467,0.9385426,0.000174434,0.001314764,0.0001347419],"study_design_scores_gemma":[0.001884995,0.001560339,0.2369162,0.0002144124,0.0001215011,0.00004343879,0.003264321,0.0001721592,0.7467826,0.0001152957,0.007796616,0.001128133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964983,0.0008863835,0.0001770877,0.0001706317,0.000346955,0.0005165333,0.001132996,0.00002708855,0.0002440115],"genre_scores_gemma":[0.9916605,0.0003520778,0.004917309,0.000183351,0.00008219072,0.000001003083,0.0009428863,0.00007597695,0.001784685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.19176,"threshold_uncertainty_score":0.9998121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006546739140028418,"score_gpt":0.2443492745916508,"score_spread":0.2378025354516223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}