{"id":"W4311852494","doi":"10.3390/antibiotics11121768","title":"Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance","year":2022,"lang":"en","type":"article","venue":"Antibiotics","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Université de Montréal; PROTEO; Centre in Green Chemistry and Catalysis","funders":"Université de Montréal; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Antibiotic resistance; Antibiotics; Trimethoprim; Biology; Dihydrofolate reductase; Drug resistance; Genetics; Microbiology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002471622,0.0002888437,0.0004020774,0.0009122691,0.0002902729,0.000590427,0.0001682013,0.0004638855,0.0004807319],"category_scores_gemma":[0.0004389625,0.000152946,0.0002742483,0.0007632061,0.0002320061,0.0003719589,0.0003793245,0.000295335,0.0002551287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776406,"about_ca_system_score_gemma":0.0002055299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097401,"about_ca_topic_score_gemma":0.00212424,"domain_scores_codex":[0.9996961,0.00004389479,0.00002789282,0.0000964848,0.00006603164,0.00006963644],"domain_scores_gemma":[0.9997476,0.00004019064,0.00009056097,0.00002959952,0.00004838701,0.00004368623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001136765,0.00002855859,0.02780758,0.00009568169,0.00002555604,0.0002576472,0.0001523208,0.0000488539,0.965841,0.00007523727,0.00003296824,0.005521021],"study_design_scores_gemma":[0.00001297511,0.0005259153,0.6370283,0.0000702984,0.0001679073,0.00544757,0.00171565,0.0009808512,0.3481286,0.000371359,0.005512672,0.00003792517],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958159,0.001400154,0.001555852,0.00007785641,0.000006465622,0.00001078937,0.0005632417,0.00002639062,0.0005433533],"genre_scores_gemma":[0.996312,0.0006370022,0.001835649,0.00005070526,0.000006110382,0.00000832816,0.0007373496,0.000008808547,0.000404031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001097401,"threshold_uncertainty_score":0.002182007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006546739140028418,"score_gpt":0.2443492745916508,"score_spread":0.2378025354516223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}