{"id":"W4311861951","doi":"10.3390/curroncol29120761","title":"Biomarker Discordances and Alterations Observed in Breast Cancer Treated with Neoadjuvant Chemotherapy: Causes, Frequencies, and Clinical Significances","year":2022,"lang":"en","type":"article","venue":"Current Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Biomarker; Breast cancer; Concordance; Oncology; Chemotherapy; Internal medicine; Cancer; Biopsy; Adjuvant; Adjuvant therapy; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001155962,0.0001330855,0.0002484391,0.0008581145,0.0001554502,0.0003177435,0.0002221125,0.0002057153,0.0004984223],"category_scores_gemma":[0.005044349,0.0001180101,0.0001919971,0.0006941397,0.000342416,0.0002814949,0.0002944792,0.000168079,0.0001026742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060648,"about_ca_system_score_gemma":0.0001442872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003027707,"about_ca_topic_score_gemma":0.0003299089,"domain_scores_codex":[0.9987908,0.0003719218,0.0002094235,0.0001938214,0.0003380847,0.00009600256],"domain_scores_gemma":[0.9962102,0.001297481,0.001827718,0.0002965227,0.0002206669,0.0001474481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002778391,0.00001107166,0.9954449,0.00001262175,0.00002397702,0.0001481787,0.00003579795,0.00003718248,0.001144826,0.000009101735,0.00001240088,0.002842003],"study_design_scores_gemma":[0.000004071707,0.0001580995,0.9962432,0.000004678771,0.00003200542,0.00198939,0.00008681004,0.0002409445,0.001064393,0.00002410398,0.0001496586,0.000002715023],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991185,0.000555331,0.0001179904,0.000009709517,0.000001943904,0.000002873872,0.00003513586,0.00000287282,0.0001556921],"genre_scores_gemma":[0.9998149,0.00005019116,0.00006300535,0.000003130214,0.000003216947,0.000001728763,0.00004568105,7.016116e-7,0.00001738618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001155962,"threshold_uncertainty_score":0.00611335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08227612880583669,"score_gpt":0.3772606086616352,"score_spread":0.2949844798557985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}