{"id":"W4311869637","doi":"10.1002/bies.202200198","title":"The cap epitranscriptome: Early directions to a complex life as mRNA","year":2022,"lang":"en","type":"article","venue":"BioEssays","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Leverhulme Trust","keywords":"Biology; Gene; Methyltransferase; Gene expression; Messenger RNA; Transcription (linguistics); Methylation; Regulation of gene expression; Translation (biology); Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004470797,0.0003312044,0.0002197509,0.0003817873,0.0004472903,0.001507983,0.0003307223,0.0008334364,0.002966519],"category_scores_gemma":[0.0005270321,0.000253991,0.0002515659,0.0003301118,0.0008934605,0.001499601,0.0005436012,0.0013599,0.001630837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006652114,"about_ca_system_score_gemma":0.0004295775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003948955,"about_ca_topic_score_gemma":0.0004627343,"domain_scores_codex":[0.9998015,0.00003625328,0.000009258204,0.00006302902,0.00005464574,0.00003535081],"domain_scores_gemma":[0.9995998,0.000086899,0.00005696052,0.00007710176,0.0001049579,0.00007431036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002550244,0.00003588778,0.001282323,0.0002739906,0.00002144008,0.000839446,0.0003975032,0.0004364587,0.8487129,0.09643854,0.002283535,0.04902281],"study_design_scores_gemma":[0.00002892013,0.0005871661,0.007768023,0.0002122832,0.00003642466,0.001832246,0.0003838059,0.003226112,0.6366427,0.04755959,0.3016286,0.00009401944],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5025384,0.08105898,0.296604,0.01508499,0.005518104,0.0001961923,0.001758007,0.001695229,0.09554602],"genre_scores_gemma":[0.8580513,0.01695828,0.06575451,0.002417824,0.001767933,0.00009686584,0.001138816,0.0002721394,0.05354236],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002966519,"threshold_uncertainty_score":0.009923995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01960868116327283,"score_gpt":0.2694405248815858,"score_spread":0.2498318437183129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}