{"id":"W4311874266","doi":"10.1002/acr2.11511","title":"Efficacy and Safety of the Bruton's Tyrosine Kinase Inhibitor Evobrutinib in Systemic Lupus Erythematosus: Results of a Phase <scp>II</scp>, Randomized, <scp>Double‐Blind</scp>, <scp>Placebo‐Controlled Dose‐Ranging</scp> Trial","year":2022,"lang":"en","type":"article","venue":"ACR Open Rheumatology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; University Health Network","funders":"EMD Serono; Merck KGaA","keywords":"Double blind; Placebo; Dose-ranging study; Medicine; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01114879,0.0009071903,0.006192875,0.0009672501,0.0006333202,0.0001001456,0.002000511,0.0006193334,0.0000394808],"category_scores_gemma":[0.03191949,0.0006751161,0.0008159555,0.001882658,0.001384064,0.0002897548,0.00355969,0.001467974,0.00002498457],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002858933,"about_ca_system_score_gemma":0.007968425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002402416,"about_ca_topic_score_gemma":0.0001671013,"domain_scores_codex":[0.9871581,0.003436927,0.004460049,0.001542848,0.001694662,0.001707457],"domain_scores_gemma":[0.9679477,0.02641497,0.002505832,0.002159744,0.0004761281,0.0004956668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9521055,0.003379988,0.0002720167,0.001461259,0.001653858,0.000446884,0.01728579,0.0003390361,0.004130278,0.002485228,0.01615842,0.0002817664],"study_design_scores_gemma":[0.9655858,0.001934435,0.00001408578,0.001406735,0.0006341108,0.006583553,0.006959168,0.005183086,0.006552705,0.0001315158,0.004901863,0.0001129905],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9652369,0.005983762,0.00002694039,0.000484587,0.00169763,0.0225996,0.0002251993,0.00009451133,0.003650884],"genre_scores_gemma":[0.9898323,0.0009463277,0.0001430548,0.0001247827,0.0001192348,0.002493183,0.0001749605,0.0001609338,0.006005242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02459539,"threshold_uncertainty_score":0.99957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248153372419936,"score_gpt":0.3187182223504038,"score_spread":0.2939028851084102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}