{"id":"W4311874266","doi":"10.1002/acr2.11511","title":"Efficacy and Safety of the Bruton's Tyrosine Kinase Inhibitor Evobrutinib in Systemic Lupus Erythematosus: Results of a Phase <scp>II</scp>, Randomized, <scp>Double‐Blind</scp>, <scp>Placebo‐Controlled Dose‐Ranging</scp> Trial","year":2022,"lang":"en","type":"article","venue":"ACR Open Rheumatology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; University Health Network","funders":"EMD Serono; Merck KGaA","keywords":"Double blind; Placebo; Dose-ranging study; Medicine; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002577258,0.001156085,0.002079523,0.0002350421,0.0003277464,0.0009830629,0.0005634887,0.001433111,0.003469762],"category_scores_gemma":[0.001792868,0.0004318974,0.001317974,0.0002506519,0.000693129,0.0007795339,0.0002125553,0.002356578,0.0005108456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005100909,"about_ca_system_score_gemma":0.0006947143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003792736,"about_ca_topic_score_gemma":0.0007631175,"domain_scores_codex":[0.9991264,0.0005314977,0.00006861075,0.0001112582,0.00007914396,0.00008316489],"domain_scores_gemma":[0.998834,0.0003957557,0.0003452172,0.00006587919,0.00008279059,0.0002765195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.944463,0.005413902,0.001438275,0.001057161,0.001502642,0.00005304271,0.0000594096,0.0005358053,0.005836251,0.00009409009,0.00163773,0.03790872],"study_design_scores_gemma":[0.9381046,0.05486542,0.004118142,0.00006660604,0.0007616809,0.00008015099,0.00001506047,0.0003172111,0.0007582662,0.0001051383,0.0007965899,0.0000112063],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978229,0.01470114,0.0005487296,0.000898582,0.0003061699,0.001369575,0.001137166,0.00007072617,0.002739079],"genre_scores_gemma":[0.9890816,0.005021253,0.0007650722,0.001043334,0.000484889,0.001047534,0.00122378,0.00001913485,0.001313388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003469762,"threshold_uncertainty_score":0.01363003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248153372419936,"score_gpt":0.3187182223504038,"score_spread":0.2939028851084102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}