{"id":"W4311883815","doi":"10.3390/genes13122392","title":"A Whole-Genome Sequencing Study Implicates GRAMD1B in Multiple Sclerosis Susceptibility","year":2022,"lang":"en","type":"article","venue":"Genes","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ministero della Salute; Michael Smith Health Research BC; Canadian Institutes of Health Research; Fondazione Italiana Sclerosi Multipla","keywords":"Missense mutation; Biology; Multiple sclerosis; Genetics; Gene; Genome; Genome-wide association study; Microglia; Phenotype; Genotype; Immunology; Inflammation; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003519962,0.0006061142,0.0003274179,0.001098784,0.0005016173,0.0004169792,0.0002601162,0.0006595917,0.003194207],"category_scores_gemma":[0.001265462,0.0001535773,0.0004116838,0.001131502,0.0002795108,0.000113094,0.0003504358,0.000428729,0.0003608665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002579007,"about_ca_system_score_gemma":0.0001493412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00222468,"about_ca_topic_score_gemma":0.002648225,"domain_scores_codex":[0.9998252,0.00004198009,0.00001634969,0.00006518139,0.00003354703,0.00001785108],"domain_scores_gemma":[0.9997106,0.00009837627,0.0000895721,0.00002429912,0.0000253098,0.00005174996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005123496,0.000164204,0.7800387,0.0004985617,0.001206985,0.01406945,0.0006753488,0.0006763175,0.124552,0.0007932391,0.00464928,0.06755237],"study_design_scores_gemma":[0.0001526597,0.0001754476,0.9736668,0.0001117775,0.0005661515,0.009628147,0.0001692496,0.0009921815,0.005988652,0.0006078323,0.007919997,0.00002101188],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910331,0.004069358,0.0009680946,0.000418828,0.00006651843,0.00002246759,0.001689282,0.00004873769,0.001683594],"genre_scores_gemma":[0.9966755,0.0008609571,0.0006904815,0.0001596635,0.00003600443,0.00001220309,0.0009303636,0.00001186413,0.0006229455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003194207,"threshold_uncertainty_score":0.01068568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1716148958209211,"score_gpt":0.3319038750054589,"score_spread":0.1602889791845378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}