{"id":"W4311901685","doi":"10.1053/j.ajkd.2022.10.016","title":"Venglustat, a Novel Glucosylceramide Synthase Inhibitor, in Patients at Risk of Rapidly Progressing ADPKD: Primary Results of a Double-Blind, Placebo-Controlled, Phase 2/3 Randomized Clinical Trial","year":2022,"lang":"en","type":"article","venue":"American Journal of Kidney Diseases","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Nierstichting; Sanofi Genzyme; ZonMw; Sanofi","keywords":"Medicine; Autosomal dominant polycystic kidney disease; Placebo; Urology; Tolerability; Renal function; Internal medicine; Interim analysis; Kidney disease; Stage (stratigraphy); Polycystic kidney disease; Randomized controlled trial; Kidney; Adverse effect; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001894048,0.002216073,0.004108485,0.0004259755,0.0003805569,0.001223384,0.0008691007,0.002201051,0.005015402],"category_scores_gemma":[0.001362461,0.0007383694,0.001898057,0.0004392635,0.001263875,0.00143629,0.0003312932,0.003093669,0.0008996255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005850535,"about_ca_system_score_gemma":0.0009132034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007517324,"about_ca_topic_score_gemma":0.001591653,"domain_scores_codex":[0.9994889,0.0002506336,0.00003054411,0.00009949856,0.00003261084,0.00009780074],"domain_scores_gemma":[0.9992537,0.0002437723,0.0001344307,0.00004882324,0.0000513999,0.0002678467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.983835,0.002460378,0.0003882409,0.0005195973,0.0007141422,0.00003513107,0.00002435829,0.0002317874,0.002275297,0.00007377526,0.0005708529,0.008871583],"study_design_scores_gemma":[0.9715521,0.02638933,0.0008496085,0.00002178769,0.0003315356,0.00002418361,0.00001472812,0.0002371322,0.0002498303,0.00008730789,0.0002310808,0.00001139149],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794596,0.01206832,0.001231342,0.000929544,0.0007321683,0.00185,0.001316086,0.00027697,0.002135927],"genre_scores_gemma":[0.9829999,0.006551506,0.001811833,0.001623402,0.0005935624,0.001931431,0.001653202,0.00004704839,0.002788155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005015402,"threshold_uncertainty_score":0.01677817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01373458003426142,"score_gpt":0.3073073225892398,"score_spread":0.2935727425549783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}