{"id":"W4311916078","doi":"10.1101/2022.12.07.22283236","title":"Towards the integrative theory of Alzheimer’s disease: linking molecular mechanisms of neurotoxicity, beta-amyloid biomarkers, and the diagnosis","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Amyloid (mycology); Cerebrospinal fluid; Neurotoxicity; Cytotoxicity; Amyloid beta; Biophysics; Extracellular; Chemistry; Pathology; Positron emission tomography; Toxicity; Fibril; BETA (programming language); In vitro; Disease; Medicine; Biochemistry; Neuroscience; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003073357,0.001043286,0.001247017,0.00162248,0.0005480541,0.002774362,0.001935147,0.001792654,0.003059476],"category_scores_gemma":[0.005190833,0.000464234,0.001371949,0.0007660898,0.003089141,0.00485074,0.002154313,0.001893341,0.0004552775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002496122,"about_ca_system_score_gemma":0.001959145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002592085,"about_ca_topic_score_gemma":0.0009894454,"domain_scores_codex":[0.9991615,0.0004177159,0.00005208138,0.0001522335,0.0001554863,0.00006113805],"domain_scores_gemma":[0.9971563,0.001550425,0.0003835179,0.0001755591,0.0005515873,0.0001827463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00008060433,0.0002275453,0.004736993,0.0002692429,0.0001127597,0.000563525,0.0003992057,0.08207294,0.003183605,0.8885982,0.002407883,0.01734742],"study_design_scores_gemma":[0.00002265774,0.00008069463,0.000860135,0.00004775986,0.00002889178,0.0001850232,0.00009418947,0.215276,0.0004203252,0.780757,0.002204088,0.00002317268],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.08957544,0.006506955,0.8614144,0.02238644,0.0005419218,0.0001376631,0.000310915,0.0001582387,0.01896792],"genre_scores_gemma":[0.8683254,0.005563361,0.1154806,0.002402704,0.001223236,0.0003499487,0.0002729797,0.00005674362,0.006325134],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003073357,"threshold_uncertainty_score":0.01811075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0505557690116646,"score_gpt":0.3228079381438971,"score_spread":0.2722521691322325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}