{"id":"W4311931858","doi":"10.1128/jvi.01723-22","title":"Nucleoside-Modified mRNA-Based Influenza Vaccines Circumvent Problems Associated with H3N2 Vaccine Strain Egg Adaptation","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Biology; Virology; Strain (injury); Adaptation (eye); Influenza vaccine; Vaccination","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090535,0.0003967325,0.0001911404,0.00007956368,0.00008400885,0.0001935327,0.0001672533,0.0003056993,0.001194653],"category_scores_gemma":[0.000183572,0.00007867355,0.0001776877,0.00005151074,0.0001753278,0.0002366427,0.0001513953,0.0005193202,0.000428501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001420851,"about_ca_system_score_gemma":0.0001441372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003034625,"about_ca_topic_score_gemma":0.0005644135,"domain_scores_codex":[0.9999136,0.00001836581,0.000004531553,0.00001619555,0.00002757759,0.00001979388],"domain_scores_gemma":[0.9999338,0.00001988502,0.00001831894,0.000007833161,0.00001209262,0.000008055588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002833384,0.000009823517,0.00004977027,0.00002340548,0.000001939268,0.00003137751,0.000006754071,0.0001003332,0.9980583,0.00008281897,0.00001938496,0.001587836],"study_design_scores_gemma":[0.000006849365,0.0005157457,0.0005608835,0.000004436738,0.00001044159,0.0001365551,0.000009725399,0.0005003529,0.9959675,0.00003537099,0.002248846,0.000003289924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966566,0.001589572,0.02634857,0.0001963345,0.000100813,0.0001242323,0.0001942765,0.0001895294,0.004690672],"genre_scores_gemma":[0.9828072,0.0008845718,0.01152591,0.00009086714,0.00002328697,0.00005626556,0.0003065722,0.00004991055,0.004255421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001194653,"threshold_uncertainty_score":0.003996551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04144963356203019,"score_gpt":0.2467278404683597,"score_spread":0.2052782069063296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}