{"id":"W4311933686","doi":"10.1016/j.chembiol.2022.11.012","title":"Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling","year":2022,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"Regulator; Biology; Interferon; Innate immune system; Signal transduction; Function (biology); Cell biology; Gene; Immune system; Embryonic stem cell; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005305106,0.0007444606,0.0005707527,0.0003436299,0.000336491,0.001041122,0.000888902,0.000775111,0.006413884],"category_scores_gemma":[0.0002971358,0.0002847277,0.0006878325,0.0002936804,0.0005364195,0.0009594562,0.0005302949,0.002699516,0.001621243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006145001,"about_ca_system_score_gemma":0.0005227565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003052133,"about_ca_topic_score_gemma":0.0005902124,"domain_scores_codex":[0.9998106,0.00003512852,0.00001773398,0.00003970135,0.00004912478,0.00004773699],"domain_scores_gemma":[0.9998552,0.00003089435,0.0000321206,0.0000223447,0.00002795984,0.00003152755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001998853,0.0006619903,0.001069114,0.000705818,0.0002282484,0.0007063867,0.000115611,0.003489407,0.9093073,0.0214462,0.004634773,0.05563635],"study_design_scores_gemma":[0.001230764,0.005513268,0.002896531,0.00008712515,0.0003244748,0.003165715,0.0002224282,0.004441264,0.8891746,0.007690234,0.08515915,0.00009447104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8025077,0.06097843,0.05894845,0.008427542,0.002087877,0.0007180194,0.005201023,0.0009886773,0.06014228],"genre_scores_gemma":[0.9401954,0.02479804,0.01584697,0.003134578,0.000185221,0.0002946429,0.003767474,0.0001264533,0.01165115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006413884,"threshold_uncertainty_score":0.02145654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442189622739874,"score_gpt":0.2510174120867085,"score_spread":0.2365955158593097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}