{"id":"W4311934160","doi":"10.1177/09564624221144489","title":"Relationship between raltegravir trough plasma concentration and virologic response and the impact of therapeutic drug monitoring during pregnancy","year":2022,"lang":"en","type":"article","venue":"International Journal of STD & AIDS","topic":"Pregnancy and Medication Impact","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Medicine; Raltegravir; Therapeutic drug monitoring; Pregnancy; Viral load; Dolutegravir; Trough level; Obstetrics; Prospective cohort study; Antiretroviral therapy; Internal medicine; Human immunodeficiency virus (HIV); Pharmacokinetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001829374,0.0001764643,0.0002749473,0.0005022147,0.0000939813,0.0005307895,0.0002381354,0.0002965186,0.0007563889],"category_scores_gemma":[0.01335362,0.0001145673,0.0004211618,0.000588247,0.0002406153,0.0003063245,0.0001975158,0.0006099653,0.00009348951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00029722,"about_ca_system_score_gemma":0.0003241764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001279347,"about_ca_topic_score_gemma":0.0009188014,"domain_scores_codex":[0.9987159,0.0006604763,0.0001563446,0.0001531216,0.000209002,0.0001053051],"domain_scores_gemma":[0.9852982,0.0101266,0.003497223,0.000274247,0.0005280314,0.0002756225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007282338,0.00002499978,0.9825005,0.00006685804,0.0001552429,0.0002210413,0.00003591977,0.0003142002,0.0005588711,0.00005020753,0.00008325579,0.01526053],"study_design_scores_gemma":[0.000008055504,0.000345997,0.9955274,0.00006785049,0.0002022508,0.001369711,0.00008373375,0.001078024,0.0007110066,0.0001040301,0.0004946171,0.000007177762],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831772,0.01358848,0.0006815249,0.0004556432,0.0000245504,0.0000124096,0.0003570789,0.000013398,0.001689612],"genre_scores_gemma":[0.9978555,0.001668884,0.0002100218,0.00004701933,0.00001918162,0.000004954951,0.00009606023,0.000003247497,0.00009513551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829374,"threshold_uncertainty_score":0.009674728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03680364431954192,"score_gpt":0.3482838915671818,"score_spread":0.3114802472476399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}