{"id":"W4311935227","doi":"10.1002/ana.26581","title":"Rare Genetic Variation and Outcome of Surgery for Mesial Temporal Lobe Epilepsy","year":2022,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Regional Development Fund; National Health and Medical Research Council; National Institute for Medical Research Development; University of Melbourne; Monash University; Epilepsy Research Program of the Ontario Brain Institute; Science Foundation Ireland; Medical Research Council; Ontario Brain Institute","keywords":"Hippocampal sclerosis; Odds ratio; Epilepsy; Medicine; Epilepsy surgery; Exome sequencing; Temporal lobe; Magnetic resonance imaging; Neuroimaging; Missense mutation; Drug Resistant Epilepsy; Exome; Internal medicine; Genetic variation; Surgery; Genetics; Biology; Psychiatry; Mutation; Population; Radiology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006058296,0.000233706,0.0002036117,0.0005480941,0.0002830607,0.000341759,0.0002287439,0.0003565117,0.001778752],"category_scores_gemma":[0.002195014,0.00008429341,0.0003368161,0.0005198078,0.0003935936,0.0001719592,0.0003842038,0.0001865821,0.0001877537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001545056,"about_ca_system_score_gemma":0.000130479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008201438,"about_ca_topic_score_gemma":0.001019884,"domain_scores_codex":[0.9996194,0.00009796904,0.00005254567,0.000113894,0.00006548096,0.00005068201],"domain_scores_gemma":[0.9982494,0.0003608982,0.001060939,0.0001026822,0.00007438031,0.000151771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002535113,0.00001570794,0.9961991,0.0000127922,0.0001065413,0.0003528731,0.00004430059,0.00008123677,0.001485417,0.00001919406,0.00003351944,0.001395863],"study_design_scores_gemma":[0.000007955125,0.00009950087,0.9983347,0.000005117766,0.0000407028,0.001035558,0.00004885711,0.0001333919,0.0001899755,0.00003679661,0.00006505004,0.00000238006],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995863,0.0001270733,0.00007066238,0.00001370345,0.000001613803,0.000001725409,0.00009652556,0.000001931519,0.0001004384],"genre_scores_gemma":[0.9997906,0.00003322455,0.00003440718,0.000005799477,0.000003144766,0.000001145816,0.0001070682,0.000001037631,0.00002361391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001778752,"threshold_uncertainty_score":0.005950511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1256192698182749,"score_gpt":0.3700446442637982,"score_spread":0.2444253744455233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}