{"id":"W4311993438","doi":"10.1136/bmjopen-2021-054958","title":"Study protocol: a randomised controlled proof-of-concept real-world study – does maximising time in range using hybrid closed loop insulin delivery and a low carbohydrate diet restore the glucagon response to hypoglycaemia in adults with type 1 diabetes?","year":2022,"lang":"en","type":"article","venue":"BMJ Open","topic":"Diabetes Management and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Edinburgh; Tandem Diabetes Care; Dexcom; University of Dundee; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Medicine; Insulin delivery; Glucagon; Protocol (science); Insulin; Closed loop; Proof of concept; Randomized controlled trial; Internal medicine; Endocrinology; Diabetes mellitus; Type 1 diabetes; Alternative medicine; Pathology; Control engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02154677,0.005361745,0.0087263,0.001373787,0.001996686,0.004067773,0.003173678,0.007330956,0.05929447],"category_scores_gemma":[0.02164711,0.002584096,0.004284402,0.001931494,0.003792612,0.003580898,0.001656506,0.006121075,0.01440335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003127433,"about_ca_system_score_gemma":0.01140197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001410079,"about_ca_topic_score_gemma":0.002837038,"domain_scores_codex":[0.9874593,0.007112612,0.001265886,0.001356283,0.001442124,0.001363774],"domain_scores_gemma":[0.9902142,0.00247098,0.002611498,0.001147065,0.001581257,0.001975064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9504285,0.008571399,0.0003792754,0.01353551,0.001072533,0.0001342106,0.0001631774,0.0006122759,0.001218498,0.001185474,0.005353843,0.01734539],"study_design_scores_gemma":[0.9338562,0.04393657,0.001427943,0.002084978,0.0005872204,0.00004727356,0.00008569512,0.0004418545,0.000397211,0.0009353374,0.0161294,0.00007035777],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.006701476,0.0006630144,0.001381287,0.0002724609,0.0007031326,0.9875507,0.00146406,0.00009380056,0.001170119],"genre_scores_gemma":[0.007685293,0.0003755969,0.002430836,0.0005322461,0.0001873131,0.9875587,0.0002774403,0.00001193683,0.0009406936],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.05929447,"threshold_uncertainty_score":0.1983597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04090172391952026,"score_gpt":0.3618356190540001,"score_spread":0.3209338951344798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}