{"id":"W4312001791","doi":"10.1172/jci164915","title":"Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Société Française d’Endocrinologie; Ligue Contre le Cancer; Recordati Rare Diseases; National Science Foundation","keywords":"Wnt signaling pathway; Endocrinology; Internal medicine; Aldosterone; Adrenal cortex; Biology; Signal transduction; Cell biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002154472,0.0001227546,0.0005798114,0.0002571198,0.0001402755,0.00001906644,0.0001095058,0.00008257668,0.0001551993],"category_scores_gemma":[0.00303071,0.0001065825,0.0002352269,0.0003558519,0.00008410947,0.0002059294,0.00008976886,0.0005738669,0.000004498677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001149124,"about_ca_system_score_gemma":0.0004032456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001391808,"about_ca_topic_score_gemma":0.000003317682,"domain_scores_codex":[0.9966657,0.0002550081,0.001780743,0.0001746778,0.0009715041,0.0001523787],"domain_scores_gemma":[0.9971924,0.0005718494,0.001096916,0.0001172004,0.0006567977,0.0003647719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005579067,0.0009403195,0.2980135,0.0004959848,0.0007171445,0.002108024,0.003994818,0.1156263,0.3766608,0.002379967,0.002380021,0.191104],"study_design_scores_gemma":[0.01049651,0.006805357,0.8360617,0.002482519,0.0008089569,0.009098994,0.001841982,0.06304331,0.05342229,0.004225159,0.01100405,0.0007091315],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935169,0.0001435907,0.001908452,0.003622225,0.000569217,0.0001751804,0.000006058263,0.00001596468,0.00004245862],"genre_scores_gemma":[0.9923968,0.00001455941,0.005632239,0.001142735,0.0006880531,0.000003046496,0.00002797679,0.00001993694,0.00007465137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5380482,"threshold_uncertainty_score":0.434631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09386215309204636,"score_gpt":0.3704240081121999,"score_spread":0.2765618550201535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}