{"id":"W4312018826","doi":"10.1126/science.abo3627","title":"Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children","year":2022,"lang":"en","type":"article","venue":"Science","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Center for Advancing Translational Sciences; National Human Genome Research Institute; Agencia Estatal de Investigación; Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Institute of Allergy and Infectious Diseases; Anschutz Medical Campus, University of Colorado; Perelman School of Medicine, University of Pennsylvania; Lékařská Fakulta v Plzni, Univerzita Karlova; National Institutes of Health; Agencia Nacional de Investigación y Desarrollo; Istanbul Üniversitesi-Cerrahpasa; Imam Abdulrahman Bin Faisal University; Vlaamse regering; Lékařská fakulta, Masarykova univerzita; Universitat Autònoma de Barcelona; Directorate for Biological Sciences; Regione Lazio; Mansoura University; Sveučilište Josipa Jurja Strossmayera u Osijeku; Science for Life Laboratory; Centre Hospitalier Universitaire Vaudois; National Cancer Institute; Université de Lausanne; Université de Genève; Honjo International Scholarship Foundation; National and Kapodistrian University of Athens; Ministerio de Ciencia e Innovación; Università degli Studi di Pavia; Fondation de France; Necmettin Erbakan Üniversitesi; Masarykova Univerzita; Universiteit Gent; Université Hassan II de Casablanca; Knut och Alice Wallenbergs Stiftelse; Yale University; Karolinska Institutet; National Science Foundation; Fundación Mapfre; Fonds Wetenschappelijk Onderzoek; Tel Aviv University; Washington University in St. Louis; KU Leuven; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Bilkent Üniversitesi; St. Giles Foundation; Ministerstvo Zdravotnictví Ceské Republiky; Genentech; European Commission; Bursa Uludağ Üniversitesi; Institut des maladies génétiques Imagine; Barcelona Institute of Science and Technology; Centres de Recerca de Catalunya; Generalitat de Catalunya; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Fondazione IRCCS Policlinico San Matteo; Ondokuz Mayis Üniversitesi; BC Children's Hospital; Université Libanaise; European Molecular Biology Organization; Case Western Reserve University; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; George Mason University; Children's Hospital Colorado; Cleveland Clinic; Sveučilište u Zagrebu; Cleveland State University; Memorial Sloan-Kettering Cancer Center; Kent State University; Fisher Center for Alzheimer's Research Foundation; Fondation du Souffle; École Polytechnique Fédérale de Lausanne; University of Pennsylvania; Hôpitaux Universitaires de Genève; Instituto Tecnológico y de Energías Renovables; Thrasher Research Fund; Agence Nationale de la Recherche; Jeffrey Modell Foundation; Universitair Ziekenhuis Gent; Universidade de São Paulo; Children's Hospital of Philadelphia; Horizon 2020 Framework Programme; Vetenskapsrådet; European Academy of Dermatology and Venereology; Georgia Clinical and Translational Science Alliance; Howard Hughes Medical Institute; Univerzita Karlova v Praze","keywords":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Medicine; Coronavirus disease 2019 (COVID-19); RNase P; Biology; Genetics; RNA; Disease; Internal medicine; Gene; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002719116,0.00141362,0.0004649655,0.001070246,0.0008026543,0.0003981818,0.0002352296,0.0005957025,0.002582579],"category_scores_gemma":[0.0008746877,0.0002700885,0.0003864158,0.0005511133,0.0008652704,0.0003320546,0.0006242611,0.0006301083,0.0003192787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004160546,"about_ca_system_score_gemma":0.0005279535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001661577,"about_ca_topic_score_gemma":0.001675418,"domain_scores_codex":[0.9996363,0.00005690184,0.00004053133,0.0000933909,0.00008477541,0.0000881587],"domain_scores_gemma":[0.9996517,0.00007083285,0.0001594078,0.00001529687,0.00002683632,0.00007593366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001238371,0.0002707074,0.5049546,0.0005567321,0.0002576296,0.3252102,0.001785938,0.0009125056,0.1345833,0.002224451,0.002747342,0.02525825],"study_design_scores_gemma":[0.00008499588,0.0009228293,0.3696073,0.0001805117,0.0003398461,0.570358,0.001066703,0.0005475514,0.04620234,0.0006195697,0.01001099,0.00005939245],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952426,0.001321845,0.001130653,0.0002446827,0.00006013639,0.0000331281,0.0003806923,0.00007913159,0.001507076],"genre_scores_gemma":[0.9978914,0.0007230561,0.0007134039,0.0000709936,0.00002802951,0.00001128087,0.0001582463,0.00001191984,0.0003917748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002582579,"threshold_uncertainty_score":0.008639574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01413347760976834,"score_gpt":0.2798903845372563,"score_spread":0.265756906927488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}