{"id":"W4312019409","doi":"10.1093/nar/gkac1134","title":"<i>CHD8</i> suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing","year":2022,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institutes of Health; Istituto Italiano di Tecnologia; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Medical Research Council; AFM-Téléthon; Università degli Studi di Trento; Autism Speaks; Simons Foundation Autism Research Initiative; Massachusetts General Hospital; Simons Foundation","keywords":"Biology; Histone H3; RNA splicing; Histone; Genetics; Alternative splicing; Splicing factor; RNA; Cell biology; Computational biology; Molecular biology; DNA; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006812929,0.0002137344,0.000131931,0.0001546126,0.00009261566,0.0001732061,0.0001525899,0.000161601,0.001501671],"category_scores_gemma":[0.0000797984,0.00006821113,0.000168103,0.00008171094,0.000209401,0.00007675346,0.0001521781,0.0002631952,0.0002327936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001448167,"about_ca_system_score_gemma":0.00007325491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006607012,"about_ca_topic_score_gemma":0.00104887,"domain_scores_codex":[0.9999115,0.000009637412,0.000008119447,0.00002786572,0.00002718656,0.00001566411],"domain_scores_gemma":[0.9999344,0.00001403184,0.00002325798,0.000007895144,0.000006007312,0.00001441831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002635367,0.000002891058,0.0002283043,0.000006066502,0.000003073808,0.00003869765,0.000003353264,0.00002173677,0.9991795,0.00003183419,0.0000143234,0.0004438549],"study_design_scores_gemma":[0.000003914851,0.00004449473,0.009088134,0.000001548812,0.00001030443,0.0002545145,0.00001309618,0.0005341714,0.9888881,0.00004461234,0.001115137,0.000002106636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946931,0.000486068,0.002794188,0.00007409391,0.000023098,0.000009117996,0.0006573162,0.0000978858,0.001165186],"genre_scores_gemma":[0.9976135,0.0001429879,0.0008253348,0.00004026965,0.000003632964,0.000006065393,0.0004465696,0.00002127946,0.0009003189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501671,"threshold_uncertainty_score":0.005023599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03322463830984666,"score_gpt":0.3642068067974963,"score_spread":0.3309821684876497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}