{"id":"W4312035679","doi":"10.1101/2022.12.08.22283237","title":"Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular risk","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Stanley Center for Psychiatric Research, Broad Institute; Knut och Alice Wallenbergs Stiftelse; Broad Institute; Fondation Leducq; Medical Research Council; American Heart Association","keywords":"Inflammasome; Inflammation; Gene; AIM2; Disease; Biology; Haematopoiesis; Gene expression; Genetics; Cancer research; Bioinformatics; Immunology; Medicine; Internal medicine; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003030739,0.000181304,0.0001764249,0.0003206973,0.0001042649,0.0002945129,0.0001096704,0.0002426024,0.003327724],"category_scores_gemma":[0.0007666693,0.0000833267,0.0001570033,0.000286969,0.0002168668,0.0000830717,0.0002668923,0.0002803927,0.0001369983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001413452,"about_ca_system_score_gemma":0.00008889857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004391914,"about_ca_topic_score_gemma":0.0004476678,"domain_scores_codex":[0.9998036,0.00006511251,0.000009449518,0.00006680903,0.0000324754,0.00002262679],"domain_scores_gemma":[0.9995807,0.0001595751,0.0001581057,0.00003927793,0.00001513159,0.00004721477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002579133,0.00008680873,0.4936614,0.0001673109,0.0003870391,0.0005735663,0.0001895043,0.002651605,0.4803351,0.00117106,0.0007031785,0.01749446],"study_design_scores_gemma":[0.00006134075,0.0004885727,0.9237182,0.00002544264,0.0001531185,0.001425138,0.0001057979,0.004991318,0.06516939,0.001337201,0.002499296,0.00002515123],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968482,0.0001867837,0.001842253,0.00003979826,0.000004569501,0.000005821973,0.000850069,0.0000251221,0.0001974985],"genre_scores_gemma":[0.9984046,0.00005550289,0.0009274937,0.00002379331,0.000003103435,0.00000784329,0.0002557368,0.000007460234,0.0003144983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003327724,"threshold_uncertainty_score":0.01113236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02748887120981792,"score_gpt":0.2852660772250643,"score_spread":0.2577772060152463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}