{"id":"W4312038352","doi":"10.3389/fmolb.2022.1060361","title":"Filamin A in platelets: Bridging the (signaling) gap between the plasma membrane and the actin cytoskeleton","year":2022,"lang":"en","type":"review","venue":"Frontiers in Molecular Biosciences","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Centre for Blood Research, University of British Columbia; Michael Smith Health Research BC; Arthritis Society","keywords":"FLNA; Filamin; Cell biology; Cytoskeleton; Actin cytoskeleton; Actin; Actin remodeling; Intracellular; Platelet activation; Cell surface receptor; Cell membrane; Signal transduction; Platelet; Chemistry; Receptor; Cell; Biology; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001890241,0.0004352058,0.001465603,0.0003630644,0.0004174966,0.0001299588,0.0008075711,0.0001666515,0.00002262863],"category_scores_gemma":[0.0003199125,0.0001904965,0.0003133606,0.001485316,0.000967474,0.0000639869,0.0002477662,0.0009415691,0.0000024925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001657115,"about_ca_system_score_gemma":0.0003019615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002403861,"about_ca_topic_score_gemma":0.000027894,"domain_scores_codex":[0.996809,0.0007479864,0.0005900266,0.000643092,0.0006814081,0.0005284926],"domain_scores_gemma":[0.9985384,0.0005569072,0.0003273971,0.0004977308,0.00001070745,0.00006887953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008563155,0.00009555716,0.0007858649,0.00120587,0.0003993578,0.001254283,0.0009556696,0.0000159152,0.00001577706,0.00008608035,0.0008898653,0.9942101],"study_design_scores_gemma":[0.003148485,0.000188873,0.0001024614,0.003050436,0.001233181,0.000412238,0.001859291,0.0005266037,0.0001437907,0.0004261673,0.9883878,0.0005207125],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0157999,0.9791352,0.0001290854,0.001801154,0.0004296644,0.002133383,0.00004093488,0.00001926603,0.0005114583],"genre_scores_gemma":[0.005231091,0.993461,0.0003767549,0.000341722,0.00005603024,0.0002864146,0.00006432939,0.00003630674,0.0001463479],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9936894,"threshold_uncertainty_score":0.7768224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02800689643781069,"score_gpt":0.2935919701078361,"score_spread":0.2655850736700254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}