{"id":"W4312051069","doi":"10.1016/j.neuron.2022.10.039","title":"RAR-alpha: Creator, protector, and tormentor","year":2022,"lang":"en","type":"letter","venue":"Neuron","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Hotchkiss Brain Institute; University of Calgary","keywords":"Neuroscience; Homeostatic plasticity; Neuropathic pain; Receptor; Psychology; Neuroplasticity; Retinoic acid; Alpha (finance); Synaptic plasticity; Biology; Medicine; Developmental psychology; Internal medicine; Metaplasticity; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0000838185,0.0003113206,0.0002193647,0.00004582337,0.000140947,0.00005645731,0.0003136532,0.0005089378,0.0003194693],"category_scores_gemma":[0.00006306294,0.0003066637,0.00009855782,0.00005672012,0.00008542628,0.000002824856,0.0003057939,0.0008568333,0.00001030619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003122703,"about_ca_system_score_gemma":0.0001336363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001318055,"about_ca_topic_score_gemma":7.405752e-7,"domain_scores_codex":[0.9983893,0.0001225131,0.000192485,0.0006996364,0.0002694147,0.0003266202],"domain_scores_gemma":[0.9992881,0.00001415413,0.0001242294,0.0004879955,0.00003296753,0.00005259322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004370202,0.00001692222,0.0001471771,0.0002481701,0.00003631077,0.0001510481,0.00001496307,7.889155e-7,0.07901863,0.000002627598,0.9196794,0.0006402449],"study_design_scores_gemma":[0.0002844938,0.0006026439,0.00004159102,0.00001069858,0.00003504507,0.00007604827,0.000007252539,0.000002183835,0.03725473,0.00002114094,0.9613611,0.0003030538],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.6951141,0.02812573,0.0001989861,0.2265112,0.005388554,0.003618035,0.0004102858,0.0002812883,0.04035178],"genre_scores_gemma":[0.02842465,0.004189898,0.0003827535,0.857123,0.01208593,0.001039146,0.003435618,0.0004625978,0.09285644],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.6666895,"threshold_uncertainty_score":0.9999385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008169347061651505,"score_gpt":0.2174334441434904,"score_spread":0.2092640970818389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}