{"id":"W4312051069","doi":"10.1016/j.neuron.2022.10.039","title":"RAR-alpha: Creator, protector, and tormentor","year":2022,"lang":"en","type":"letter","venue":"Neuron","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Hotchkiss Brain Institute; University of Calgary","keywords":"Neuroscience; Homeostatic plasticity; Neuropathic pain; Receptor; Psychology; Neuroplasticity; Retinoic acid; Alpha (finance); Synaptic plasticity; Biology; Medicine; Developmental psychology; Internal medicine; Metaplasticity; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002651776,0.0008782809,0.001171286,0.0005127119,0.002297798,0.00248105,0.001214791,0.03237671,0.004715284],"category_scores_gemma":[0.008761136,0.0005419648,0.00113019,0.0003046914,0.002226189,0.001552374,0.0006745315,0.02290932,0.004359094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003449613,"about_ca_system_score_gemma":0.002075457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003938154,"about_ca_topic_score_gemma":0.009002497,"domain_scores_codex":[0.9985709,0.0003795991,0.0001515852,0.0002005198,0.0005005903,0.0001968968],"domain_scores_gemma":[0.9968295,0.002237767,0.0001683142,0.000116964,0.0003281983,0.0003192879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004835092,0.00009002988,0.0007448203,0.00007258865,0.00004918147,0.003753276,0.00009311967,0.0001189338,0.000953063,0.008588566,0.966475,0.01857789],"study_design_scores_gemma":[0.0006618735,0.0002145987,0.001489792,0.0001938451,0.0000953532,0.003003637,0.0003140844,0.001273807,0.002067123,0.02014703,0.9704565,0.00008223731],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001098972,0.003365332,0.0004494075,0.9587951,0.0303274,0.00004929362,0.0001250056,0.00006209697,0.005727361],"genre_scores_gemma":[0.01525262,0.004842671,0.001094272,0.8732872,0.06157836,0.0001970535,0.00009490214,0.0000591646,0.04359394],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03237671,"threshold_uncertainty_score":0.02502882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008169347061651505,"score_gpt":0.2174334441434904,"score_spread":0.2092640970818389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}