{"id":"W4312060640","doi":"10.1101/2022.12.09.519777","title":"p38γ and p38δ modulate innate immune response by regulating MEF2D activation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Medical Research Council; Agencia Estatal de Investigación; Ministerio de Educación y Formación Profesional; Universidad Autónoma de Madrid; Cancer Research UK; Wellcome Trust; Francis Crick Institute; Centro Nacional de Biotecnología; University of Dundee","keywords":"p38 mitogen-activated protein kinases; Innate immune system; Cell biology; Biology; MEF2C; Inflammation; Transcription factor; Immune system; Kinase; Protein kinase A; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673177,0.0004935878,0.000147222,0.0003444252,0.0001755001,0.0002343643,0.0002221315,0.0002344653,0.001980973],"category_scores_gemma":[0.00009700221,0.000159661,0.0002366089,0.0001232291,0.0002836813,0.0002042869,0.0002324988,0.0005302717,0.0004002694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002308115,"about_ca_system_score_gemma":0.000124077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001752696,"about_ca_topic_score_gemma":0.0002309804,"domain_scores_codex":[0.9998535,0.00002045446,0.00001339897,0.00003738845,0.0000314655,0.00004377135],"domain_scores_gemma":[0.9999057,0.000009734689,0.00003388169,0.000009520528,0.000009600672,0.00003155562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001619164,0.00002375836,0.0002465702,0.00003187429,0.000003070337,0.00003930814,0.000008729585,0.00003524467,0.998591,0.00006238066,0.00002782857,0.0007683134],"study_design_scores_gemma":[0.00003966253,0.0001513572,0.007450978,0.000009582472,0.000009254901,0.000183997,0.00003243496,0.0006139069,0.990119,0.000122968,0.001262942,0.000003944778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917153,0.001825835,0.003999077,0.0001780975,0.00003913149,0.00003647189,0.000649217,0.00009291545,0.001464099],"genre_scores_gemma":[0.9942577,0.0006413369,0.002198929,0.00005387517,0.00001240963,0.00006930122,0.000325199,0.00001432269,0.002426938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001980973,"threshold_uncertainty_score":0.006626964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009305685861567265,"score_gpt":0.2120714432267684,"score_spread":0.2027657573652011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}