{"id":"W4312064967","doi":"10.1038/s41514-022-00097-8","title":"Multiple pathways promote microtubule stabilization in senescent intestinal epithelial cells","year":2022,"lang":"en","type":"article","venue":"npj Aging","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Microtubule; Cell biology; Senescence; Biology; Tubulin; Phenotype; Homeostasis; Intestinal epithelium; Epithelium; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002020601,0.0003739257,0.0003250393,0.0006538295,0.0003332578,0.000560045,0.0001418378,0.0003007668,0.001961479],"category_scores_gemma":[0.0001840071,0.0001486847,0.0003824231,0.0002753757,0.0001668813,0.0004068493,0.0003868068,0.000482412,0.0004537833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004148979,"about_ca_system_score_gemma":0.0002847934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002526517,"about_ca_topic_score_gemma":0.0006019232,"domain_scores_codex":[0.9998887,0.00001657589,0.00001384941,0.00002747908,0.00002552298,0.00002789279],"domain_scores_gemma":[0.9998111,0.0000218116,0.00005915233,0.0000137601,0.00004606137,0.00004819284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002188195,0.00004127613,0.0006248208,0.0001419411,0.00001191327,0.000190557,0.00003503069,0.00005453002,0.995056,0.0002757293,0.0001265136,0.00322286],"study_design_scores_gemma":[0.00004747171,0.0003593666,0.02394633,0.00004288704,0.00004763411,0.0004062479,0.0001111996,0.001201228,0.9651666,0.0003784416,0.008279182,0.00001343901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631566,0.02201074,0.007853467,0.0005166201,0.0001724969,0.0001300541,0.0009581913,0.000418263,0.004783606],"genre_scores_gemma":[0.9888517,0.00464024,0.002038416,0.00008363758,0.0000410116,0.00008391649,0.0005089031,0.00002070296,0.003731549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001961479,"threshold_uncertainty_score":0.006561756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02056742551762235,"score_gpt":0.2395670753042274,"score_spread":0.218999649786605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}