{"id":"W4312064980","doi":"10.1007/s40268-022-00410-6","title":"A Randomised Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of Palovarotene Ophthalmic Solution","year":2022,"lang":"en","type":"article","venue":"Drugs in R&D","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"Ipsen","keywords":"Tolerability; Medicine; Pharmacokinetics; Adverse effect; Placebo; Internal medicine; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001208547,0.00009313943,0.0002994632,0.0000641146,0.00009080311,0.000005989376,0.00009854277,0.00001408386,0.00015297],"category_scores_gemma":[0.0000761249,0.00007135413,0.00005319188,0.0002554895,0.0000294041,0.00002288392,0.0001512267,0.0002168706,0.000001606948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000704106,"about_ca_system_score_gemma":0.00005895343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001405135,"about_ca_topic_score_gemma":0.000009305607,"domain_scores_codex":[0.9987363,0.0003106123,0.0003150441,0.0001952815,0.0002960152,0.0001467895],"domain_scores_gemma":[0.9994049,0.0001452922,0.00006160062,0.0002879509,0.00004447012,0.00005580384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05932929,0.0179766,0.6654193,0.0003056435,0.0005352118,0.000266078,0.05292473,0.002340884,0.1512431,0.0001463218,0.0002353554,0.04927749],"study_design_scores_gemma":[0.3249092,0.008241562,0.5709973,0.0001342634,0.000995949,0.00007558747,0.05041346,0.01662884,0.02098507,0.0002872676,0.00560164,0.0007298131],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961125,0.0001988303,0.0001261705,0.001199104,0.0001141366,0.001830234,0.00001663006,0.0000116226,0.0003908029],"genre_scores_gemma":[0.9994409,0.00001904704,0.00008392263,0.0002383578,0.00002393529,0.00009791046,0.000007285303,0.000009935477,0.00007868401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2655799,"threshold_uncertainty_score":0.2909737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03184393169426662,"score_gpt":0.3427165005340247,"score_spread":0.3108725688397581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}