{"id":"W4312064980","doi":"10.1007/s40268-022-00410-6","title":"A Randomised Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of Palovarotene Ophthalmic Solution","year":2022,"lang":"en","type":"article","venue":"Drugs in R&D","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"Ipsen","keywords":"Tolerability; Medicine; Pharmacokinetics; Adverse effect; Placebo; Internal medicine; Anesthesia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002961912,0.001406871,0.002856658,0.0004294272,0.0004451253,0.001007485,0.001004323,0.00160953,0.01260067],"category_scores_gemma":[0.002994615,0.0009102551,0.001132416,0.0004882244,0.001284292,0.001103892,0.0004361319,0.001989285,0.001600865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007353728,"about_ca_system_score_gemma":0.002380225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004462856,"about_ca_topic_score_gemma":0.001126203,"domain_scores_codex":[0.9987969,0.0006075015,0.00008464738,0.0002369844,0.0001284673,0.0001454765],"domain_scores_gemma":[0.9980313,0.0004814218,0.0005733728,0.0002141096,0.0001925146,0.0005073029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9570636,0.01831567,0.0006119755,0.0007366334,0.0004550267,0.00006397129,0.0000666205,0.0002294339,0.009407289,0.0001716816,0.0008341134,0.01204408],"study_design_scores_gemma":[0.7990611,0.1976726,0.0008999429,0.00003340773,0.0001831509,0.00004314616,0.00002042269,0.0001932018,0.0004873023,0.0001334385,0.001261005,0.00001127357],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9359109,0.004524433,0.003622415,0.0008154596,0.001320275,0.04733936,0.002973693,0.0002130575,0.003280387],"genre_scores_gemma":[0.9339051,0.003465626,0.007626011,0.001964744,0.0007967277,0.04137836,0.001889045,0.00005660763,0.008917917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01260067,"threshold_uncertainty_score":0.04215342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03184393169426662,"score_gpt":0.3427165005340247,"score_spread":0.3108725688397581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}