{"id":"W4312065570","doi":"10.12703/r-01-0000019","title":"A Genetic roadmap to the DNA damage response to genotoxic agents in human cells","year":2022,"lang":"en","type":"letter","venue":"Faculty Reviews","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"DNA damage; DNA repair; DNA; Biology; Gene; CRISPR; Cancer; Computational biology; Cancer cell; Genome; Human genome; Cancer research; Genetics; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002900389,0.001172791,0.0009087776,0.0007427913,0.001367552,0.002484045,0.001433819,0.01373713,0.008724624],"category_scores_gemma":[0.005732602,0.0005476672,0.0008833623,0.0004255721,0.003056128,0.003519732,0.001606595,0.01832344,0.007838793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003065914,"about_ca_system_score_gemma":0.001794738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000885348,"about_ca_topic_score_gemma":0.002076652,"domain_scores_codex":[0.9981743,0.0005799209,0.0001307379,0.0002315013,0.0006980441,0.0001855162],"domain_scores_gemma":[0.9964442,0.002078535,0.0001602789,0.0001911235,0.0006945816,0.0004314537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000300392,0.0001380008,0.0001456574,0.0006449927,0.00003432163,0.001762712,0.0001002146,0.0003015096,0.007391215,0.02632513,0.8639386,0.09891725],"study_design_scores_gemma":[0.000108069,0.000167903,0.0002242877,0.0001873368,0.00001438779,0.0008791157,0.00005296116,0.0001812836,0.001594713,0.01794275,0.9786248,0.00002243796],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.001538478,0.1271985,0.003828456,0.7681965,0.07967489,0.0001202991,0.0001788783,0.0003314525,0.01893251],"genre_scores_gemma":[0.02133474,0.1845413,0.003846665,0.6158892,0.1399767,0.0003528077,0.0002366717,0.0001639942,0.03365797],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01373713,"threshold_uncertainty_score":0.02918679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04911214785320672,"score_gpt":0.3242916542635373,"score_spread":0.2751795064103306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}