{"id":"W4312066037","doi":"10.1186/s13195-022-01134-0","title":"Association of neurofilament light chain with renal function: mechanisms and clinical implications","year":2022,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Temple University; F. Hoffmann-La Roche; Biogen; University of California, San Diego; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Bristol-Myers Squibb; Eli Lilly and Company; National Institute on Aging; Alzheimer's Association; H. Lundbeck A/S; U.S. Department of Veterans Affairs","keywords":"Neurodegeneration; Medicine; Biomarker; Creatinine; Renal function; Internal medicine; Neurology; Cerebrospinal fluid; Cystatin C; Endocrinology; Physiology; Disease; Biology; Psychiatry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00335606,0.0004854324,0.0006834655,0.000885723,0.0004823807,0.0009390151,0.0007795658,0.0007411368,0.001251613],"category_scores_gemma":[0.004910986,0.0002916274,0.0005757638,0.0009355654,0.001270438,0.0007144865,0.0007116721,0.0007691562,0.0001243873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004943565,"about_ca_system_score_gemma":0.0006062577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002446435,"about_ca_topic_score_gemma":0.002413268,"domain_scores_codex":[0.9989567,0.0003461125,0.00008405144,0.0003324366,0.0001776897,0.0001030643],"domain_scores_gemma":[0.9967367,0.0008839329,0.001662134,0.0003274306,0.0002141408,0.0001755919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000432739,0.000060477,0.9920533,0.00004488615,0.0002490829,0.0002246558,0.0001413179,0.0001324703,0.001527821,0.0002385369,0.00005873764,0.004836043],"study_design_scores_gemma":[0.00001491224,0.0001029564,0.9969188,0.00001779451,0.000109037,0.000906695,0.00009209427,0.0004227643,0.0005394944,0.0007198846,0.0001475748,0.00000797631],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926115,0.005372737,0.0009570876,0.0003834715,0.0000120718,0.00001566214,0.0001405022,0.00001015336,0.0004968618],"genre_scores_gemma":[0.998669,0.0006046287,0.0004850708,0.00005093473,0.00002259144,0.000009451019,0.00005398709,0.000002592334,0.0001017102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00335606,"threshold_uncertainty_score":0.01774871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06621771843706073,"score_gpt":0.3690339572312682,"score_spread":0.3028162387942075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}