{"id":"W4312066765","doi":"10.1038/s41418-022-01092-y","title":"Cholinergic control of Th17 cell pathogenicity in experimental autoimmune encephalomyelitis","year":2022,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Toronto Centre for Phenogenomics; Princess Margaret Cancer Centre; University Health Network","funders":"CIHR Skin Research Training Centre; Canadian Institutes of Health Research; Weill Cornell Medical College; Government of Canada; European Molecular Biology Organization","keywords":"Experimental autoimmune encephalomyelitis; Choline acetyltransferase; Cholinergic; Immune system; Biology; Interleukin 17; Immunology; T cell; Multiple sclerosis; Cell biology; RAR-related orphan receptor gamma; Signal transduction; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001692916,0.0001396697,0.0002572088,0.0001363489,0.000202281,0.000008765158,0.0001257896,0.00008334845,0.001035482],"category_scores_gemma":[0.000008259096,0.0001365631,0.00008023188,0.00009034676,0.00005673498,0.00006981917,0.00007276698,0.0002013265,0.000008703158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004193881,"about_ca_system_score_gemma":0.00003547739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001549447,"about_ca_topic_score_gemma":0.00000134651,"domain_scores_codex":[0.9988239,0.0003777713,0.0003259273,0.0002035927,0.00004632765,0.0002224226],"domain_scores_gemma":[0.9995603,0.00008485265,0.0001570687,0.0001683675,0.00001848352,0.00001095909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007014329,0.0004719294,0.01042278,0.00001550656,0.00001885865,0.00000204404,0.001176416,0.00005226604,0.9858092,0.0001844747,0.00001838412,0.001126699],"study_design_scores_gemma":[0.006605639,0.0004784966,0.405056,0.000008110128,0.00002575797,0.00001447321,0.0008586065,0.0002004572,0.5852678,0.00006978209,0.001225726,0.0001891303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9634795,0.03520181,0.0002383774,0.00001643391,0.0003421781,0.0002266358,0.00004744033,0.0000197253,0.0004279369],"genre_scores_gemma":[0.9982054,0.0003141085,0.00001272094,0.00005878439,0.000007101843,0.00006720184,0.0001727306,0.00001104258,0.00115092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4005414,"threshold_uncertainty_score":0.9998777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007667959551637124,"score_gpt":0.2123525235609723,"score_spread":0.2046845640093352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}