{"id":"W4312067329","doi":"10.1002/psc.3471","title":"Opening the amino acid toolbox for peptide‐based NTS2‐selective ligands as promising lead compounds for pain management","year":2022,"lang":"en","type":"review","venue":"Journal of Peptide Science","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Réseau québécois de recherche sur la douleur; Fonds de Recherche du Québec - Santé; Vrije Universiteit Brussel","keywords":"Medicine; G protein-coupled receptor; Pharmacology; Context (archaeology); Neurotensin; In vivo; Opioid; Analgesic; Chronic pain; Adverse effect; Receptor; Chemistry; Internal medicine; Neuropeptide; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000274826,0.0006975693,0.0006156288,0.0009276421,0.0002155366,0.0006536327,0.0005560597,0.0007979323,0.005434101],"category_scores_gemma":[0.0002776996,0.0002720425,0.0004141449,0.0006820246,0.000283149,0.001102382,0.0005632659,0.001782903,0.003010758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003311662,"about_ca_system_score_gemma":0.0004589256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000370642,"about_ca_topic_score_gemma":0.000814303,"domain_scores_codex":[0.9999125,0.00001487398,0.000008302884,0.00001735207,0.00003130309,0.0000156176],"domain_scores_gemma":[0.9999282,0.00002845108,0.0000118319,0.000003563985,0.00001831246,0.000009571287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001814329,0.0002138443,0.0001851932,0.01909347,0.0001035241,0.0006541522,0.0001279287,0.001516186,0.04746815,0.01985206,0.03495503,0.875649],"study_design_scores_gemma":[0.0000307207,0.0002435944,0.0003680635,0.0009169971,0.0000621486,0.0008586274,0.00003213017,0.000320241,0.006474409,0.002636306,0.9880326,0.00002410785],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001692725,0.9881403,0.001805855,0.0004596552,0.0005402422,0.00002633619,0.00009747019,0.00005483373,0.007182411],"genre_scores_gemma":[0.008000498,0.9856471,0.001535933,0.0004554166,0.0002389793,0.0000380995,0.0001433009,0.00000949635,0.003931127],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005434101,"threshold_uncertainty_score":0.01817888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.126213495615444,"score_gpt":0.3739612476279324,"score_spread":0.2477477520124884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}