{"id":"W4312067461","doi":"10.1038/s42003-022-04254-3","title":"Repeated dosing improves oncolytic rhabdovirus therapy in mice via interactions with intravascular monocytes","year":2022,"lang":"en","type":"article","venue":"Communications Biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary; Institute of Cancer Research; Alberta Children's Hospital","funders":"CIHR Skin Research Training Centre; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Alberta Children's Hospital Foundation; Canada Research Chairs; Government of Canada; Children's Hospital Foundation; Ottawa Hospital Research Institute","keywords":"Oncolytic virus; Vesicular stomatitis virus; Dosing; Tumor microenvironment; Virus; Proinflammatory cytokine; Monocyte; Viral replication; Intravital microscopy; Immunology; CD8; Virology; Biology; Medicine; Immune system; Inflammation; Pharmacology; In vivo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004488971,0.0001556126,0.0001753859,0.0001879305,0.0004182786,0.00001989204,0.001082261,0.00007423246,0.0000723501],"category_scores_gemma":[0.00004190796,0.0001472989,0.00006762096,0.0004030554,0.0002986593,0.00000686381,0.000641369,0.0004378786,0.000008603472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001156507,"about_ca_system_score_gemma":0.0001798369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003230705,"about_ca_topic_score_gemma":0.001873199,"domain_scores_codex":[0.9981769,0.0008329122,0.0002682665,0.0003538583,0.00007905906,0.0002889466],"domain_scores_gemma":[0.9980297,0.00009314137,0.0001049234,0.001630397,0.00008955168,0.00005228546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001151767,0.0002759096,0.001513632,0.000002212135,0.0001204595,0.000001425577,0.0001636761,0.0002238556,0.9584051,0.00005549824,0.00009069232,0.03799579],"study_design_scores_gemma":[0.00513045,0.01477658,0.003466817,0.00002409894,0.00004132009,0.0001962028,0.00142266,0.006676579,0.7422938,0.0007682221,0.2242448,0.000958518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903808,0.006485904,0.0004082629,0.00138853,0.0000597241,0.0004858193,0.00002102434,0.00003108802,0.0007388878],"genre_scores_gemma":[0.9949145,0.002227369,0.001175854,0.0004558158,0.0000340956,0.0005198164,0.0004701765,0.00003210725,0.000170313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2241541,"threshold_uncertainty_score":0.6006673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03366622912456463,"score_gpt":0.3364536564578185,"score_spread":0.3027874273332539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}