{"id":"W4312068953","doi":"10.1172/jci.insight.150849","title":"Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; BC Children's Hospital; Agricultural Research Institute of Ontario; University of Ottawa; AGADA Biosciences; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Genome Canada; AllerGen; Genome British Columbia; Michael Smith Health Research BC; Canadian Allergy, Asthma and Immunology Foundation","keywords":"Immune system; Immunology; Zebrafish; Immune dysregulation; Eosinophilia; Inflammation; Allergic inflammation; Transcriptome; Disease; Phenotype; Medicine; Ruxolitinib; Biology; Interleukin 13; Cancer research; Genetics; Interleukin 4; Gene; Internal medicine; Bone marrow","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000100942,0.0006420861,0.0002708794,0.0004538389,0.0002175637,0.0002149205,0.0001439978,0.0005035746,0.002292149],"category_scores_gemma":[0.0001166893,0.0001312648,0.0003195395,0.0002391244,0.0003239383,0.00009046705,0.0002911981,0.0006743396,0.0003243465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002797081,"about_ca_system_score_gemma":0.0002347376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006357003,"about_ca_topic_score_gemma":0.001526785,"domain_scores_codex":[0.9998611,0.00001980768,0.00001414857,0.00003501233,0.00004045116,0.00002940901],"domain_scores_gemma":[0.9999176,0.00001795905,0.00002824714,0.00000594941,0.000003182602,0.00002701159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000378971,0.00008570627,0.002541599,0.00006606472,0.00002785584,0.004329514,0.00003784859,0.0003294764,0.9853056,0.0003313862,0.0004051373,0.006160964],"study_design_scores_gemma":[0.000374983,0.001771338,0.1925774,0.0001011092,0.000269545,0.07445311,0.0003174432,0.00829396,0.7012491,0.001425601,0.01909908,0.00006723867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994512,0.001060034,0.001308636,0.0002170197,0.00004417895,0.00004699623,0.001160637,0.0001551407,0.001495312],"genre_scores_gemma":[0.9967405,0.0005242997,0.001015637,0.0001121561,0.00001526131,0.00002072919,0.0005529868,0.00002858951,0.0009897677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002292149,"threshold_uncertainty_score":0.007668018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362987200254261,"score_gpt":0.2081931887091323,"score_spread":0.1945633167065897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}