{"id":"W4312068953","doi":"10.1172/jci.insight.150849","title":"Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; BC Children's Hospital; Agricultural Research Institute of Ontario; University of Ottawa; AGADA Biosciences; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Genome Canada; AllerGen; Genome British Columbia; Michael Smith Health Research BC; Canadian Allergy, Asthma and Immunology Foundation","keywords":"Immune system; Immunology; Zebrafish; Immune dysregulation; Eosinophilia; Inflammation; Allergic inflammation; Transcriptome; Disease; Phenotype; Medicine; Ruxolitinib; Biology; Interleukin 13; Cancer research; Genetics; Interleukin 4; Gene; Internal medicine; Bone marrow","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001515352,0.0001355908,0.0002158849,0.0001544229,0.0004614269,0.000007978208,0.0000939905,0.0001413632,0.0009736328],"category_scores_gemma":[0.00002374966,0.0001304146,0.00004604958,0.0002007128,0.0001002313,0.0001121594,0.0001234939,0.0002171097,0.00004928646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004425196,"about_ca_system_score_gemma":0.00004766198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009870484,"about_ca_topic_score_gemma":0.00008387816,"domain_scores_codex":[0.9990485,0.0002067088,0.0002853538,0.0002215117,0.0000526307,0.0001852998],"domain_scores_gemma":[0.9995188,0.00003585642,0.0001592034,0.0001991096,0.00007216616,0.00001483182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001727047,0.0001000956,0.001105954,0.00005271426,0.0002252241,0.000006651568,0.003490771,0.0001403018,0.9803667,0.004748165,0.007223884,0.002366852],"study_design_scores_gemma":[0.002810943,0.00105209,0.04005824,0.00003138103,0.0001258093,0.0001087689,0.001656469,0.00002300353,0.1677753,0.001429226,0.7844902,0.0004385644],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922362,0.0007093395,0.00002219367,0.0000823904,0.0004830172,0.0001800573,0.0002595838,0.00007316752,0.005954046],"genre_scores_gemma":[0.9951983,0.00004539919,0.00001016812,0.00008974096,0.00003915937,0.00002692045,0.0005039211,0.00001455578,0.004071849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8125914,"threshold_uncertainty_score":0.9999396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362987200254261,"score_gpt":0.2081931887091323,"score_spread":0.1945633167065897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}