{"id":"W4312069235","doi":"10.21203/rs.3.rs-2322502/v1","title":"Development of DHES0815A; a novel HER2-directed antibody-drug conjugate comprised of a reduced potency mono-alkylating agent linked to a domain I binding HER2 antibody","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Seagen (Canada)","funders":"Genentech; MacroGenics; Pfizer","keywords":"Conjugate; Potency; Antibody; Chemistry; Antibody-drug conjugate; Pharmacology; Drug; Medicine; Biochemistry; Monoclonal antibody; Immunology; In vitro; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003019592,0.0003916802,0.000310106,0.0001884807,0.0001018244,0.0003325462,0.0004252278,0.0004008969,0.001070144],"category_scores_gemma":[0.0001687679,0.0002253237,0.0002580647,0.0001142886,0.0001665093,0.0002601435,0.0002157825,0.0005369436,0.000588662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003924947,"about_ca_system_score_gemma":0.0003731754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006743209,"about_ca_topic_score_gemma":0.00085634,"domain_scores_codex":[0.9998788,0.00001904248,0.000009777559,0.00003151951,0.00003698405,0.00002389564],"domain_scores_gemma":[0.9999415,0.000005335988,0.0000121699,0.000007875197,0.00001226161,0.00002091594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003074224,0.0003073948,0.0002872513,0.00007682702,0.00003316876,0.0001204414,0.00002836123,0.0009222285,0.9783249,0.0006224464,0.0004217963,0.01854781],"study_design_scores_gemma":[0.0001097238,0.001174584,0.0004133031,0.000003186711,0.00002409249,0.0002610333,0.000004531682,0.00127705,0.98948,0.00002794892,0.007219381,0.00000525251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9635492,0.002524154,0.02486724,0.0004535834,0.0001899476,0.0007538482,0.0009163423,0.0003018216,0.006443921],"genre_scores_gemma":[0.9795187,0.001117103,0.01171252,0.00009547889,0.0000147678,0.0001070203,0.00102091,0.00002684533,0.006386746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001070144,"threshold_uncertainty_score":0.003579974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1234031637901417,"score_gpt":0.4697713062184486,"score_spread":0.3463681424283069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}