{"id":"W4312073676","doi":"10.3390/cancers15010048","title":"Co-Targeting Luminal B Breast Cancer with S-Adenosylmethionine and Immune Checkpoint Inhibitor Reduces Primary Tumor Growth and Progression, and Metastasis to Lungs and Bone","year":2022,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Centre for Interdisciplinary Research in Rehabilitation; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Metastasis; Breast cancer; Cancer research; Medicine; Cancer; Combination therapy; Bone metastasis; Primary tumor; In vivo; Immune system; Immunotherapy; Mammary tumor; Oncology; Internal medicine; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001318033,0.000365041,0.0005391666,0.0003701418,0.0001406267,0.00018138,0.0002438161,0.0003130871,0.0009774039],"category_scores_gemma":[0.00007146909,0.0001345481,0.0003354553,0.0001942965,0.0002234257,0.0002192476,0.0002021335,0.0007773857,0.0001707899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001782157,"about_ca_system_score_gemma":0.0002855759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000803544,"about_ca_topic_score_gemma":0.001937068,"domain_scores_codex":[0.9998838,0.00001977372,0.000009024813,0.00002111559,0.00003369784,0.00003249913],"domain_scores_gemma":[0.9999533,0.000005406215,0.00001285847,0.000005700754,0.00000418421,0.00001863335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001306027,0.0006342047,0.0004014581,0.0001473764,0.00004006034,0.00005198859,0.00002528811,0.0001580364,0.9870088,0.00008181293,0.0001989878,0.009946066],"study_design_scores_gemma":[0.0002929106,0.01270194,0.00799709,0.00001878883,0.0001455606,0.0004090431,0.00007081321,0.00157697,0.969588,0.00006636007,0.007120103,0.00001254961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930448,0.004195419,0.0009075985,0.0001944758,0.00006493964,0.00004955362,0.0001475446,0.000108726,0.001286862],"genre_scores_gemma":[0.994276,0.002179944,0.00133102,0.00008454532,0.00002760151,0.00006228312,0.0002382293,0.00001209617,0.001788263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009774039,"threshold_uncertainty_score":0.003269732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00806834896806137,"score_gpt":0.2665250228545035,"score_spread":0.2584566738864421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}