{"id":"W4312083660","doi":"10.1016/j.jmb.2022.167927","title":"Targeting G Protein-Coupled Receptors in the Treatment of Parkinson’s Disease","year":2022,"lang":"en","type":"review","venue":"Journal of Molecular Biology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"","keywords":"Neurodegeneration; Dopaminergic; Neuroscience; Dopamine; Parkinson's disease; G protein-coupled receptor; Neuroprotection; Receptor; Dopamine receptor; Medicine; Pharmacology; Disease; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000531106,0.001098498,0.001896367,0.001801128,0.0002241711,0.0008459758,0.001002177,0.001215213,0.00317554],"category_scores_gemma":[0.0004589042,0.0002530244,0.0005733955,0.001548323,0.0004763903,0.0008478626,0.0005500705,0.002663707,0.002076925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004846723,"about_ca_system_score_gemma":0.0005991408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001119852,"about_ca_topic_score_gemma":0.002863486,"domain_scores_codex":[0.9998647,0.00002183371,0.00001672794,0.0000208316,0.00005774137,0.00001824718],"domain_scores_gemma":[0.999823,0.00006990526,0.00003247944,0.000004509889,0.00004470845,0.00002529255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001948448,0.0001660056,0.00007541848,0.01280728,0.0001465037,0.0002048168,0.00003899956,0.000494453,0.003816959,0.002760791,0.03122977,0.9480641],"study_design_scores_gemma":[0.0001874843,0.0004729534,0.001145119,0.004164364,0.000399663,0.001600675,0.00004915238,0.0003392818,0.001288451,0.002782092,0.9875286,0.00004217241],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001122359,0.9988772,0.0001276014,0.0001825837,0.000181986,0.000005384081,0.00001297616,0.000008601546,0.0004914228],"genre_scores_gemma":[0.0008034143,0.998143,0.000202627,0.0001754972,0.0001572713,0.000006402907,0.00002435479,0.000001302376,0.0004861121],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00317554,"threshold_uncertainty_score":0.01062322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03397205487855615,"score_gpt":0.3337155499183646,"score_spread":0.2997434950398085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}