{"id":"W4312086030","doi":"10.1002/alz.069243","title":"Biological variation of Alzheimer’s disease plasma biomarkers in healthy individuals","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Biomarker; Medicine; Coefficient of variation; Neurodegeneration; Disease; Oncology; Internal medicine; Alzheimer's disease; Pathology; Biology; Statistics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001875091,0.000285195,0.0003323279,0.00051339,0.000313145,0.0004079225,0.0002651838,0.0004011432,0.000494402],"category_scores_gemma":[0.003031312,0.0001671998,0.0002200578,0.0004613254,0.0003315984,0.0001762003,0.0002565105,0.0001984211,0.0001624745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000179491,"about_ca_system_score_gemma":0.0001100309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001190476,"about_ca_topic_score_gemma":0.0009762546,"domain_scores_codex":[0.9981766,0.0008386459,0.0001154694,0.0005450058,0.0002519417,0.00007249564],"domain_scores_gemma":[0.9983705,0.0005535584,0.0002881794,0.0004003013,0.0003015165,0.00008615071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00555477,0.0004885377,0.8734565,0.0001573459,0.0007857783,0.0003294906,0.001168379,0.0009680293,0.08785614,0.000280348,0.0008639675,0.02809072],"study_design_scores_gemma":[0.00004501314,0.00120249,0.992754,0.000006020653,0.00009240855,0.0002769573,0.0001248848,0.0007358706,0.003905462,0.0002006187,0.0006424336,0.00001379563],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948211,0.0006142691,0.003329996,0.00001812675,0.00001919804,0.0000420005,0.000484656,0.00002671968,0.0006439708],"genre_scores_gemma":[0.9980072,0.00006027544,0.00107657,0.00003197235,0.000011275,0.00007042674,0.0004530245,0.000009905828,0.0002792733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001875091,"threshold_uncertainty_score":0.009916544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4067215494275842,"score_gpt":0.4847678190632385,"score_spread":0.07804626963565431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}