{"id":"W4312086075","doi":"10.1002/alz.069246","title":"Polygenic risk score association with cognitive decline in Parkinson’s Disease","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Montreal Cognitive Assessment; Cohort; Genome-wide association study; Cognition; Medicine; Disease; Cognitive decline; Demography; Internal medicine; Psychology; Cognitive impairment; Dementia; Psychiatry; Biology; Genetics; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001839119,0.0003715877,0.0004229221,0.001182747,0.0004863268,0.0008620396,0.0003379931,0.0005013802,0.003242739],"category_scores_gemma":[0.004941222,0.0001560695,0.00100287,0.00156821,0.0003440355,0.0003118044,0.0006515324,0.0006373173,0.0001907679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002771254,"about_ca_system_score_gemma":0.0003132402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00587739,"about_ca_topic_score_gemma":0.00591849,"domain_scores_codex":[0.9987327,0.0005411584,0.0001058322,0.0003846443,0.0001355007,0.0001000874],"domain_scores_gemma":[0.997066,0.001482336,0.000642474,0.0003728199,0.0002283029,0.0002081608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005382714,0.00004179282,0.9859948,0.00003973352,0.001043683,0.0001816317,0.0001119051,0.001297994,0.001886222,0.0003392209,0.0003017189,0.008223089],"study_design_scores_gemma":[0.000009980294,0.0000997808,0.9933335,0.00001020774,0.0002131485,0.0002561526,0.00004570429,0.005000313,0.0001977636,0.000588057,0.0002370543,0.000008339714],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942954,0.0003835103,0.003574363,0.0001229195,0.00001142416,0.00001297693,0.001086486,0.00004736942,0.0004656332],"genre_scores_gemma":[0.9985406,0.00004505163,0.0007979195,0.00001124457,0.000006321746,0.000009048352,0.0004345084,0.000005760804,0.0001496644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00587739,"threshold_uncertainty_score":0.01168633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01881296649563367,"score_gpt":0.2635420096252227,"score_spread":0.244729043129589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}