{"id":"W4312086180","doi":"10.1002/alz.069285","title":"Plasma levels of an N‐terminal tau fragment predict core AD and neurodegenerative biomarkers in autosomal dominant Alzheimer’s disease: Findings from DIAN","year":2022,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Neurodegeneration; Cognitive decline; Clinical Dementia Rating; Dementia; Internal medicine; Oncology; Alzheimer's disease; Medicine; Cerebrospinal fluid; Disease; Pathology; Neuroscience; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001077701,0.0007488021,0.0004219349,0.0006691208,0.0003739362,0.0005287988,0.0003744354,0.000358091,0.001085914],"category_scores_gemma":[0.002127875,0.0002687812,0.0003121923,0.0004965703,0.0002970231,0.00027134,0.0004405238,0.0005117342,0.0002739467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003139231,"about_ca_system_score_gemma":0.0002858003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004514104,"about_ca_topic_score_gemma":0.004175455,"domain_scores_codex":[0.9996361,0.0001212493,0.00003263633,0.0001254243,0.0000514945,0.00003309942],"domain_scores_gemma":[0.9988846,0.0003636561,0.0003048072,0.0001296502,0.0001261402,0.0001911689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007857757,0.00006413589,0.9950212,0.00001075284,0.0000973828,0.0001215924,0.00008341508,0.00006140234,0.00199829,0.00001973697,0.00007234094,0.001664001],"study_design_scores_gemma":[0.00001370363,0.0001126427,0.9982292,0.000003471097,0.00005388638,0.0003845091,0.00006334622,0.0006188577,0.0002933706,0.00005193116,0.0001706793,0.000004577438],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992889,0.0001450329,0.0001270067,0.00002079066,0.000003216212,0.00000361406,0.0001659038,0.000003179772,0.0002423329],"genre_scores_gemma":[0.9993712,0.00003867663,0.0001670958,0.00001482947,0.000003204193,0.000003794688,0.0002235776,0.000001773081,0.0001758657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004514104,"threshold_uncertainty_score":0.008975625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04173369367546892,"score_gpt":0.3041711333747381,"score_spread":0.2624374396992691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}